Algae‐derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split‐mouth clinical, radiological, and histologic randomized study in humans

Objectives To analyze a modified biphasic phycogenic biomaterial in comparison with anorganic bovine bone in maxillary sinus floor elevation in humans. Material and methods Eight male patients in need of bilateral two‐stage sinus floor elevation were consecutively recruited for this randomized split...

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Published in:Clinical oral implants research 2020-06, Vol.31 (6), p.536-548
Main Authors: Galindo‐Moreno, Pablo, Padial‐Molina, Miguel, Lopez‐Chaichio, Lucia, Gutiérrez‐Garrido, Lourdes, Martín‐Morales, Natividad, O'Valle, Francisco
Format: Article
Language:English
Subjects:
Algae
anorganic bovine bone
Biomaterials
Biomedical materials
Biopsy
bone biomaterial
Bone biomaterials
Bone grafts
Bone growth
Bone healing
Bone surgery
Cortical bone
Dental implants
Dentistry
Elevation
Fibroblasts
Grafting
Hydroxyapatite
implant dentistry
Maxillary sinus
maxillary sinus augmentation
Mineralization
morphology
Osteogenesis
Patients
phycogenic biomaterial
Randomization
Sinuses
Statistical analysis
Statistical methods
ultrastructure
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Summary:Objectives To analyze a modified biphasic phycogenic biomaterial in comparison with anorganic bovine bone in maxillary sinus floor elevation in humans. Material and methods Eight male patients in need of bilateral two‐stage sinus floor elevation were consecutively recruited for this randomized split‐mouth study. A combination of autogenous cortical bone (ACB, 20%) and anorganic bovine bone (ABB, 80%) (ACB + ABB group) or ACB (20%) and modified biphasic phycogenic material (BP, 80%) (ACB + BP group) were randomly assigned to graft each sinus. Patients were followed up for 6 months post‐surgery when bone samples were collected for analysis. Results Radiographically, bone height gain was statistically higher in the ACB + ABB versus the ACB + BP group. While the analysis of the biological compartments showed differences in non‐mineralized tissue (39.15 ± 20.97% vs. 65.87 ± 28.59%, ACB + ABB vs. ACB + BP respectively; p = .018) and remnant biomaterial particles (22.62 ± 17.01% vs. 7.96 ± 8.57%, respectively; p = .028), the percentage of mineralized tissue (38.23 ± 17.55% vs. 24.14 ± 24.66%, respectively; p = .398) showed no statistically significant difference. In contrast, ACB + ABB biopsies showed higher Musashi‐1‐positive cells per mm2 compared to ACB + BP biopsies (811.49 ± 875.30 vs. 236.90 ± 280.81; p 
ISSN:0905-7161
1600-0501
DOI:10.1111/clr.13590