Osmotherapy in traumatic brain injury

The clinical use of both hyperosmolar agents has evolved over more than 100 years, following the emergence of evidence from experimental models, small cohort studies, and experience-justified treatment, and is now engrained in clinical practice and guidelines. To help address this uncertainty, the U...

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Bibliographic Details
Published in:Lancet neurology 2020-03, Vol.19 (3), p.208-208
Main Authors: Rowland, Matthew J, Veenith, Tonny, Hutchinson, Peter J, Perkins, Gavin D
Format: Article
Language:English
Subjects:
Brain Edema - therapy
Brain Injuries, Traumatic - therapy
Brain research
Clinical medicine
Humans
Intracranial pressure
Mannitol - therapeutic use
Medical research
Osmotic pressure
Saline Solution, Hypertonic - therapeutic use
Traumatic brain injury
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Summary:The clinical use of both hyperosmolar agents has evolved over more than 100 years, following the emergence of evidence from experimental models, small cohort studies, and experience-justified treatment, and is now engrained in clinical practice and guidelines. To help address this uncertainty, the UK National Institute for Health Research has funded the Sugar or Salt (SOS) trial (registered with ISRCTN.com, ISRCTN16075091). Igor Stevanovic/Science Photo Library The SOS trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme (HTA 17/120/01) and supported by the NIHR Applied Research Centre West Midlands.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(20)30003-X