Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM ar...

Full description

Saved in:
Bibliographic Details
Published in:Microbes and infection 2020-09, Vol.22 (8), p.379-383
Main Authors: Mourão, Luiza Carvalho, Medeiros, Camila Maia Pantuzzo, Cardoso-Oliveira, Gustavo Pereira, Roma, Paula Magda da Silva, Aboobacar, Jamila da Silva Sultane, Rodrigues, Beatriz Carolina Medeiros, Agero, Ubirajara, Fontes, Cor Jesus Fernandes, Braga, Érika Martins
Format: Article
Language:English
Subjects:
ABO blood groups
IgG
IgM
Membrane deformability
Phagocytosis
Plasmodium vivax
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2020.02.003