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Living-Donor Liver Transplantation for Patients With Extrahepatic Malignancy: A Series of 14 Patients in a Single Institution

Extrahepatic malignancy is a relative contraindication for liver transplant in many countries. Nevertheless, the indications for living-donor liver transplantation (LDLT) for such patients vary by institution. Our aim was to reevaluate the indications for LDLT in patients with extrahepatic malignanc...

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Bibliographic Details
Published in:Transplantation proceedings 2020-04, Vol.52 (3), p.889-893
Main Authors: Kosai-Fujimoto, Yukiko, Yoshizumi, Tomoharu, Tomiyama, Takahiro, Morinaga, Akinari, Iseda, Norifumi, Inokuchi, Shoichi, Yugawa, Kyohei, Yoshiya, Shohei, Toshima, Takeo, Takeishi, Kazuki, Itoh, Shinji, Harada, Noboru, Ikegami, Toru, Mori, Masaki
Format: Article
Language:English
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Summary:Extrahepatic malignancy is a relative contraindication for liver transplant in many countries. Nevertheless, the indications for living-donor liver transplantation (LDLT) for such patients vary by institution. Our aim was to reevaluate the indications for LDLT in patients with extrahepatic malignancy. We retrospectively reviewed data for 609 patients who underwent adult LDLT from May 1997 to January 2018 and analyzed patients with a history of extrahepatic malignancies or concurrent malignancies. Fourteen patients had extrahepatic malignancies concurrent with or before LDLT. Malignancies in 9 patients were detected during their systematic screening for LDLT. The mean duration between surgeries was 70 days (range, 20-209 days). Five patients had a history of extrahepatic malignancies before considering LDLT. The estimated 5-year survival rate was 100%. Although the risk and long-term prognosis of patients with extrahepatic malignancy are not well known, such patients can be candidates for LDLT if they undergo curative surgery for the malignancy, and if the prognosis of the malignancy is the same or superior to that of LDLT. •Extrahepatic malignancy before liver transplantation was seen in 14 out of 609 patients undergoing living-donor liver transplantation.•Most of the patients with extrahepatic malignancy underwent liver transplantation first and the surgeries for malignancy afterwards because those patients were at a higher risk of excessive blood loss during surgeries for malignancy.•The prognosis after liver transplantation of these patients was not inferior to patients without malignancies, although a few concerns remain regarding immunosuppressant and posttransplant recurrence.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2019.12.041