Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

• Published in: Echocardiography (Mount Kisco, N.Y.) N.Y.), 2020-04, Vol.37 (4), p.536-545
• Main Authors: Papamichail, Nikos, Bechlioulis, Aris, Lakkas, Lampros, Bougiakli, Mara, Giannitsi, Sophia, Gouva, Chariklia, Katopodis, Kostas, Michalis, Lampros K., Naka, Katerina K.
• Format: Article
• Language: English
• Subjects: coronary flow reserve; diastolic function; echocardiography; end‐stage renal disease; left ventricular function
• ISSN: 0742-2822; 1540-8175
• DOI: 10.1111/echo.14625

Introduction Coronary vascular dysfunction, as assessed by coronary flow reserve (CFR) in the left anterior descending coronary artery, is found in various conditions including end‐stage chronic kidney disease (CKD). Currently, we investigated the associations of CFR with echocardiographic indices of systolic and diastolic cardiac function and identified independent predictors of CFR in hemodialysis patients. Methods End‐stage CKD patients treated with hemodialysis (n = 29) without known cardiovascular disease were recruited from a Hemodialysis Unit in Northwestern Greece. A thorough echocardiographic evaluation including CFR measurement following dipyridamole infusion was performed in all participants. Arterial stiffness was assessed by measurement of carotid–femoral pulse wave velocity and aortic augmentation index. Results The mean age of the patients was 63 years, and mean duration of hemodialysis was 2.9 years. CFR was 1.60 ± 0.37 while dipyridamole caused a significant increase in E'sep, Slat, E'lat, and Stroke volume (P