Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

Abstract In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively found in nonsecretor patients. Unlike VP8* from P[8]...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2020-08, Vol.222 (5), p.836-839
Main Authors: Khachou, Amira, Le Moullac-Vaidye, Béatrice, Peltier, Cécile, Breiman, Adrien, Imbert-Marcille, Berthe-Marie, Ruvoen-Clouet, Nathalie, Aouni, Mahjoub, Mastouri, Maha, Chouchane, Slaheddine, Le Pendu, Jacques
Format: Article
Language:English
Subjects:
Child, Preschool
Children
Fucosyltransferases - genetics
Galactoside 2-alpha-L-fucosyltransferase
Gastroenteritis
Genotype
Host Specificity
Humans
Infant
Infant, Newborn
Phenotype
Phenotypes
Polysaccharides
Polysaccharides - metabolism
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Rotavirus
Rotavirus - genetics
Rotavirus - physiology
Rotavirus Infections - genetics
Saliva
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
Virus Attachment
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively found in nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donor’s secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow cocirculation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa122