Drug Delivery and Drug Efficacy from Amorphous Poly(thioether anhydrides)

The correlation between erosion and drug (lidocaine and 6‐mercaptopurine, 6‐MP) release from amorphous poly(thioether anhydrides), which are synthesized using radical‐mediated thiol‐ene polymerization, is reported. Cytotoxicity studies of the polymer toward human fibroblast human dermal fibroblasts...

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Bibliographic Details
Published in:Macromolecular bioscience 2020-05, Vol.20 (5), p.e1900377-n/a
Main Authors: Snyder, Brittany L., Mohammed, Halimatu S., Samways, Damien S. K., Shipp, Devon A.
Format: Article
Language:English
Subjects:
6-Mercaptopurine
Anhydrides
Autoimmune diseases
Biocompatibility
Breast cancer
Cancer
Cytotoxicity
Drug delivery
Drug delivery systems
Fibroblasts
Lidocaine
Melanoma
poly(thioether anhydride)
Polyanhydrides
Polymerization
Polymers
surface erosion
Toxicity
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Summary:The correlation between erosion and drug (lidocaine and 6‐mercaptopurine, 6‐MP) release from amorphous poly(thioether anhydrides), which are synthesized using radical‐mediated thiol‐ene polymerization, is reported. Cytotoxicity studies of the polymer toward human fibroblast human dermal fibroblasts adult, melanoma A‐375, and breast cancer MCF‐7 cells are conducted, and drug efficacy of a cancer and autoimmune disease drug (6‐MP) when released from the poly(thioether anhydrides) is examined against two cancerous cell types (A‐375 and MCF‐7). Erosion and drug release studies reveal that lidocaine release is governed by network erosion whereas 6‐MP is released by a combination of erosion and diffusion. The cytotoxicity studies show that all three cell types demonstrate high viability, thus cytocompatibility, to poly(thioether anhydrides). Toxicity to the material is dose dependent and comparable to other polyanhydride systems. The 6‐MP cancer drug is shown to remain bioactive after encapsulation in the poly(thioether anhydride) matrix and the polymer does not appear to modify the efficacy of the drug. Poly(thioether anhydrides) erosion and drug release are correlated and the efficacy of a cancer drug (6‐mercaptopurine) is high when released from the poly(thioether anhydrides). Lidocaine release is controlled largely by degradation processes rather than diffusion from the polymer network, whereas 6‐mercaptopurine is released by a combination of degradation and diffusion.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201900377