The impact of sarcopenia and myosteatosis on postoperative outcomes and 5-year survival in curatively operated colorectal cancer patients – A retrospective register study

The aim of this study was to evaluate whether sarcopenia or myosteatosis have an impact on short- and long-term results in patients who were surgically treated for colorectal cancer. During 2007–2011 curatively treated colorectal cancer patients (n = 348) were included in the study. Clinical data wa...

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Bibliographic Details
Published in:European journal of surgical oncology 2020-09, Vol.46 (9), p.1656-1662
Main Authors: Aro, Raila, Mäkäräinen-Uhlbäck, Elisa, Ämmälä, Noora, Rautio, Tero, Ohtonen, Pasi, Saarnio, Juha, Meriläinen, Sanna
Format: Article
Language:English
Subjects:
Adipose Tissue - diagnostic imaging
Adult
Aged
Aged, 80 and over
Anastomotic Leak - epidemiology
Body Composition
Carcinoma - epidemiology
Carcinoma - pathology
Carcinoma - surgery
Colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female
Heart Diseases - epidemiology
Heart Failure - epidemiology
Humans
Kaplan-Meier Estimate
Lung Diseases - epidemiology
Male
Middle Aged
Muscle, Skeletal - diagnostic imaging
Myocardial Infarction - epidemiology
Myosteatosis
Patient Discharge
Pleural Effusion - epidemiology
Pneumonia - epidemiology
Postoperative Complications - epidemiology
Prognosis
Proportional Hazards Models
Pulmonary Embolism - epidemiology
Registries
Respiratory Insufficiency - epidemiology
Retrospective Studies
Sarcopenia
Sarcopenia - diagnostic imaging
Sarcopenia - epidemiology
Survival Rate
Tomography, X-Ray Computed
Young Adult
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Summary:The aim of this study was to evaluate whether sarcopenia or myosteatosis have an impact on short- and long-term results in patients who were surgically treated for colorectal cancer. During 2007–2011 curatively treated colorectal cancer patients (n = 348) were included in the study. Clinical data was collected retrospectively from patient registers. Skeletal muscle mass was measured at the L3 level via venous-phase computed tomography and patients were divided into sarcopenic and non-sarcopenic and into myosteatotic and non-myosteatotic. Postoperative morbidity and mortality were analysed in these groups. Sarcopenia was found in 208 patients (59.8%) and myosteatosis was found in 108 patients (31.2%). Sarcopenia was associated with increased risk of postoperative pneumonia (6.7% vs. 1.4%, p = 0.021). Sarcopenic colon cancer patients had higher rate of cardiorespiratory complications than non-sarcopenic (6.3% vs. 0.0%, p = 0.023) and sarcopenic rectum cancer patients had more often pneumonia than non-sarcopenic (8.5% vs. 0.0%, p = 0.041). Discharge to home was less common in myosteatotic patients than in non-myosteatotic patients (47.7% vs. 76.9%, p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2020.03.206