Recurrence of clinical events at the same anatomical location in patients with MOG antibody-associated disease

Objectives: Likelihood of clinical events occurring within the same anatomical location in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) was retrospectively investigated. Methods: A total of 236 clinical events in 90 patients with MOGAD from nine referral hosp...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis 2021-03, Vol.27 (3), p.449-452
Main Authors: Hyun, Jae-Won, Kwon, Young Nam, Lee, Hye Lim, Jeong, Woo Kyo, Lee, Hye Jung, Kim, Byoung Joon, Kim, Seung Woo, Shin, Ha Young, Shin, Hyun-June, Oh, Sun-Young, Lee, Min Young, Kim, Su-Hyun, Huh, So-Young, Kim, Woojun, Park, Min Su, Kim, Sun-Young, Kim, Sung-Min, Kim, Ho Jin
Format: Article
Language:English
Subjects:
Brain stem
Central nervous system
Cerebellum
Myelin
Oligodendrocyte-myelin glycoprotein
Optic nerve
Patients
Spinal cord
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: Likelihood of clinical events occurring within the same anatomical location in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) was retrospectively investigated. Methods: A total of 236 clinical events in 90 patients with MOGAD from nine referral hospitals were analyzed via logistic regression, and odds ratios (ORs) were calculated. Anatomical lesion location was divided into four groups; optic nerve, spinal cord, cerebral hemisphere, and brainstem/cerebellum. Results: At all locations, there was an increased likelihood of a second attack occurring at the same location as the initial event (cerebral hemisphere OR = 22.14, brainstem/cerebellum OR = 18.4, spinal cord OR = 9.1, and optic nerve OR = 7.8). There was an increased likelihood of a third attack occurring at the same location as the initial event in the optic nerve (OR = 14.9), cerebral hemisphere (OR = 11.7), and spinal cord (OR = 6.7). There were positive trends toward a third clinical event occurring at the same location as the first and/or second events if the event was in the optic nerve (OR = 13.5), cerebral hemisphere (OR = 6.9), or spinal cord (OR = 5.7). Conclusions: The current study suggests that clinical relapses of MOGAD during early stage tend to recur at the same anatomical locations in the central nervous system.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458520913970