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In vitro degradability and bioactivity of oxidized bacterial cellulose-hydroxyapatite composites

[Display omitted] •This work describes in vitro degradation of BC/HA membranes.•The oxidation degree modulates the BC degradability.•The glucose amount in the product degradation increases with the oxidation degree.•The OxBC/HA are more bioactive and degradable than BC/HA.•These oxidized hybrid comp...

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Bibliographic Details
Published in:Carbohydrate polymers 2020-06, Vol.237, p.116174-116174, Article 116174
Main Authors: Luz, Erika Patricia Chagas Gomes, Chaves, Paulo Hiago Silva, Vieira, Lidia de Araújo Pinto, Ribeiro, Sádwa Fernandes, Borges, Maria de Fátima, Andrade, Fabia Karine, Muniz, Celli Rodrigues, Infantes-Molina, Antonia, Rodríguez-Castellón, Enrique, Rosa, Morsyleide de Freitas, Vieira, Rodrigo Silveira
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Language:English
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Summary:[Display omitted] •This work describes in vitro degradation of BC/HA membranes.•The oxidation degree modulates the BC degradability.•The glucose amount in the product degradation increases with the oxidation degree.•The OxBC/HA are more bioactive and degradable than BC/HA.•These oxidized hybrid composites are interesting for bone regeneration applications. Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2020.116174