Loading…
In vitro degradability and bioactivity of oxidized bacterial cellulose-hydroxyapatite composites
[Display omitted] •This work describes in vitro degradation of BC/HA membranes.•The oxidation degree modulates the BC degradability.•The glucose amount in the product degradation increases with the oxidation degree.•The OxBC/HA are more bioactive and degradable than BC/HA.•These oxidized hybrid comp...
Saved in:
Published in: | Carbohydrate polymers 2020-06, Vol.237, p.116174-116174, Article 116174 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | [Display omitted]
•This work describes in vitro degradation of BC/HA membranes.•The oxidation degree modulates the BC degradability.•The glucose amount in the product degradation increases with the oxidation degree.•The OxBC/HA are more bioactive and degradable than BC/HA.•These oxidized hybrid composites are interesting for bone regeneration applications.
Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications. |
---|---|
ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2020.116174 |