Hydrogen bonded capsules by layer-by-layer assembly of tannic acid and poly(2-n-propyl-2-oxazoline) for encapsulation and release of macromolecules

We report hydrogen bonded capsules with the built-in ability to release loaded bioactive molecules at a physiological temperature of 37 °C. The use of neutral and non-toxic building blocks such as tannic acid (TA) and poly(2-n-propyl-2-oxazoline)s (PnPropOx) as hydrogen bonding donor and acceptor re...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-12, Vol.5 (45), p.8967-8974
Main Authors: Paramasivam, Gokul, Vergaelen, Maarten, Ganesh, Munuswamy-Ramanujam, Hoogenboom, Richard, Sundaramurthy, Anandhakumar
Format: Article
Language:English
Subjects:
Biocompatibility
Chemical bonds
Drug delivery
Drug delivery systems
Hydrogen
Hydrogen bonding
Macromolecules
Pore formation
Probes
Scanning electron microscopy
Tannic acid
Temperature effects
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Summary:We report hydrogen bonded capsules with the built-in ability to release loaded bioactive molecules at a physiological temperature of 37 °C. The use of neutral and non-toxic building blocks such as tannic acid (TA) and poly(2-n-propyl-2-oxazoline)s (PnPropOx) as hydrogen bonding donor and acceptor results in stable hollow capsules. The temperature induced morphological changes of the shell were investigated using a scanning electron microscope and an optical microscope and revealed pore formation in the shell when the temperature (T) increases beyond the cloud point temperature (T ) of PnPropOx. Furthermore, confocal laser scanning microscopic investigation of the hollow capsules loaded with different probes of varying hydrodynamic diameters revealed that the open and closed state of the capsules could be effectively manipulated by varying the incubation time and hydrodynamic radius of the probes. Such hydrogen bonded capsules have high potential for use in temperature responsive sustained drug delivery applications.
ISSN:2050-750X
2050-7518
DOI:10.1039/c7tb02284k