Role of Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Bladder Pain Syndrome/Interstitial Cystitis

Some recent studies evaluated the introduction of diffusion-weighted magnetic resonance imaging (DW-MRI) in the diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC). To evaluate whether DW-MRI can contribute to noninvasive diagnosis of BPS/IC. The agreement between two raters (2 radiolo...

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Published in:Urology (Ridgewood, N.J.) N.J.), 2020-07, Vol.141, p.55-59
Main Authors: Daniele, Porru, Cesare, Regina, Bright, Oworae Howardson, Nicolo, Fiorello, Barbara, Gardella, Federica, Manzoni, Catherine, Klersy, Gabriella, Sala Maria, Alfredo, La Fianza, Daniela, Ballerini, Lorenzo, Preda, Claudio, Simeone, Arsenio, Spinillo, Hussein, Jallous
Format: Article
Language:English
Subjects:
Adult
Aged
Cystitis, Interstitial - diagnostic imaging
Cystoscopy
Diffusion Magnetic Resonance Imaging
Female
Genital Diseases, Female - diagnostic imaging
Humans
Middle Aged
Pain - diagnostic imaging
Syndrome
Urinary Bladder - diagnostic imaging
Urinary Bladder Diseases - diagnostic imaging
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Summary:Some recent studies evaluated the introduction of diffusion-weighted magnetic resonance imaging (DW-MRI) in the diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC). To evaluate whether DW-MRI can contribute to noninvasive diagnosis of BPS/IC. The agreement between two raters (2 radiologists involved in the study) was also evaluated, the relevance of the "operator-dependent" factor defined. Twenty-two female patients with a diagnosis of BPS-IC were recruited and performed DW-MRI. The same investigation was also performed in 20 patients with pelvic gynecological diseases and no BPS-IC. A significant difference was found between BPS-IC and no-BPS-IC since 17 out of 22 subjects of the first group were positive, compared to 3 out of 20 no-IC subjects, with a P value of .001 to highlight the statistical significance. The sensitivity of the exam was 77%, while the specificity was 85%. There was good agreement between the 2 raters in the evaluation of MRI results. DW-MRI helps to obtain a noninvasive diagnosis of BPS/IC, by providing useful information on the choice of which patients may be more appropriately submitted to cystoscopy and bladder biopsy.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2020.03.019