Campomanesia sp. flour attenuates non‐alcoholic fatty liver disease on rats fed with a hypercaloric diet

Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to eval...

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Published in:Journal of animal physiology and animal nutrition 2020-09, Vol.104 (5), p.1575-1582
Main Authors: Loubet Filho, Paulo Sérgio, Santos, Thayná Gil, Reis, Vitória Helena de Oliveira Teixeira, Santee, Cynthia Monteiro, Costa, Matheus Pereira, Cândido, Camila Jordão, Filiú, Wander Fernando de Oliveira, Portugal, Luciane Candeloro, Santos, Elisvânia Freitas
Format: Article
Language:English
Subjects:
Antioxidants
Bioactive compounds
Biochemical analysis
Chemical composition
Chemical compounds
Cholesterol
Consumption
Diet
dietary fibre
Fatty liver
Flour
Food consumption
Glucose
Glucose tolerance
High density lipoprotein
Liver
Liver diseases
Metabolic disorders
non‐alcoholic fatty liver disease
obesity
Phenolic compounds
Phenols
phytochemicals
Pulp
Residues
Seeds
Steatosis
Triglycerides
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Summary:Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to evaluate the effects of the flour from guavira's industrial residue (GF) consumption in rats fed with hypercaloric diet (HD). During 65 days, 50 rats were separated into a control group: 1%, 2%, 4% and 8% HD with GF complementation in the diet. The GF chemical composition, phenolic compounds, antioxidant capacity, serum biochemical parameters (glucose, cholesterol, HDL, non‐HDL, triglycerides, AST, ALT, and oral glucose tolerance test), fat liver content, and hepatic histomorphology had been characterized. GF is mainly composed of fibres, with phenolic content of 7,391.09 mg AGE/100 g GF and relevant antioxidant capacity (IC50 2.22 and ORAC 155.68 μmol/TE g−1). Serum biochemical analysis did not differ statistically (except ALT reduction, p 
ISSN:0931-2439
1439-0396
DOI:10.1111/jpn.13361