Effect of a Chikungunya Virus–Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial

IMPORTANCE: Chikungunya virus (CHIKV) is a mosquito-borne Alphavirus prevalent worldwide. There are currently no licensed vaccines or therapies. OBJECTIVE: To evaluate the safety and tolerability of an investigational CHIKV virus–like particle (VLP) vaccine in endemic regions. DESIGN, SETTING, AND P...

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Published in:JAMA : the journal of the American Medical Association 2020-04, Vol.323 (14), p.1369-1377
Main Authors: Chen, Grace L, Coates, Emily E, Plummer, Sarah H, Carter, Cristina A, Berkowitz, Nina, Conan-Cibotti, Michelle, Cox, Josephine H, Beck, Allison, O’Callahan, Mark, Andrews, Charla, Gordon, Ingelise J, Larkin, Brenda, Lampley, Rebecca, Kaltovich, Florence, Gall, Jason, Carlton, Kevin, Mendy, Jason, Haney, Doug, May, Jeanine, Bray, Amy, Bailer, Robert T, Dowd, Kimberly A, Brockett, Brittanie, Gordon, David, Koup, Richard A, Schwartz, Richard, Mascola, John R, Graham, Barney S, Pierson, Theodore C, Donastorg, Yeycy, Rosario, Nicolas, Pape, Jean William, Hoen, Bruno, Cabié, André, Diaz, Clemente, Ledgerwood, Julie E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Antibodies
Antibodies, Neutralizing - blood
Chikungunya Fever - immunology
Chikungunya Fever - prevention & control
Chikungunya virus
Chikungunya virus - immunology
Clinical trials
Complications
Dilution
Double-Blind Method
Durability
Female
Humans
Immune response
Immune system
Immunosuppressive agents
Infections
Injections, Intramuscular
Male
Middle Aged
Mosquitoes
Neutralization
Neutralization Tests
Original Investigation
Safety
Vaccines
Vaccines, Virus-Like Particle - administration & dosage
Vaccines, Virus-Like Particle - adverse effects
Vaccines, Virus-Like Particle - immunology
Vector-borne diseases
Viral Vaccines - administration & dosage
Viral Vaccines - adverse effects
Viral Vaccines - immunology
Virus-like particles
Viruses
Young Adult
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