A presentation, treatment, and survival analysis of primary cardiac lymphoma cases reported from 2009 to 2019

The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. H...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2020-07, Vol.112 (1), p.65-73
Main Authors: Chen, Haoguang, Qian, Shenxian, Shi, Pengfei, Liu, Lirong, Yang, Fan
Format: Article
Language:English
Subjects:
Arrhythmia
B-cell lymphoma
Case reports
Central nervous system
Complications
Diagnostic systems
Epidemiology
Heart
Hematology
Lymphocytes B
Lymphoma
Medical prognosis
Medical treatment
Medicine
Medicine & Public Health
Oncology
Original Article
Patients
Prognosis
Prophylaxis
Statistical analysis
Surgery
Survival
Survival analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. However, some aspects must be discussed further in light of recent advances in lymphoma research. We collected cardiac lymphoma case reports published from January 2009 to January 2019, collected statistics from each patient, and performed a systematic analysis. The epidemiological characteristics, clinical manifestations, treatments, responses, and survival of primary cardiac lymphoma (PCL) patients are described. We obtained 158 cases of heart lymphoma, of which 101 were defined as PCL. There were more male than female cases. Most cases were diffuse large B-cell lymphoma. Six cases of PCL in cardiac myxomas were described. Patients with arrhythmia had shorter progression-free survival compared those without (HR 0.334, 95% CI 0.112–0.999, log-rank P  = 0.042). Surgery did not improve patients’ long-term prognosis or reduce the risk of death within 1 month. These data suggest that central nervous system prophylaxis is necessary. The overall survival was longer than that in data from 1949 to 2009.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-020-02881-2