Hyperuricemia is associated with decreased renal function and occurrence of end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis: a retrospective study

• Published in: Rheumatology international 2020-07, Vol.40 (7), p.1089-1099
• Main Authors: Kwon, Hyeok Chan, Ahn, Sung Soo, Yoo, Byung-Woo, Yoo, Juyoung, Jung, Seung Min, Song, Jason Jungsik, Park, Yong-Beom, Lee, Sang-Won
• Format: Article
• Language: English
• Subjects: Aged; Antibodies, Antineutrophil Cytoplasmic - immunology; Case-Control Studies; Creatinine; Female; Glomerular Filtration Rate; Granulomatosis with Polyangiitis - epidemiology; Granulomatosis with Polyangiitis - immunology; Granulomatosis with Polyangiitis - metabolism; Health risk assessment; Humans; Hyperuricemia - epidemiology; Hyperuricemia - metabolism; Inflammatory diseases; Kidney diseases; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - metabolism; Logistic Models; Male; Medicine; Medicine & Public Health; Microscopic Polyangiitis - epidemiology; Microscopic Polyangiitis - immunology; Microscopic Polyangiitis - metabolism; Middle Aged; Myeloblastin - immunology; Observational Research; Peroxidase - immunology; Proportional Hazards Models; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - metabolism; Retrospective Studies; Rheumatology; Risk Factors; Uric acid; Vein & artery diseases
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-020-04579-4

Current evidence suggests that high uric acid levels are associated with accelerated renal damage. However, the clinical impact of serum uric acid level on patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) is unknown. We aimed to evaluate the impact of hyperuricemia on such patients. A retrospective study was performed to obtain patients’ demographic, clinical, and laboratory data from when they were diagnosed with MPA and GPA. Multivariable logistic regression and Cox hazard model analyses were performed to evaluate factors associated with hyperuricemia at diagnosis and predictive factors of end-stage renal disease (ESRD) development. Among 156 patients, 35 (22.4%) had hyperuricemia at baseline. Hyperuricemic patients had renal manifestation and impaired renal function more frequently than non-hyperuricemic patients. Logistic regression analysis revealed that serum creatinine was significantly associated with hyperuricemia at diagnosis [odds ratio 1.995; 95% confidence interval (CI), 1.503–2.648; P