Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)

• Published in: European journal of paediatric neurology 2020-07, Vol.27, p.78-85
• Main Authors: Edmonds, Caroline J., Helps, Suzannah K., Hart, Denise, Zatorska, Anna, Gupta, Neelam, Cianfaglione, Rina, Vollmer, Brigitte
• Format: Article
• Language: English
• Subjects: Minor neurological signs; Neonatal hypoxic ischaemic encephalopathy (HIE); Neurodevelopmental; Neuromotor; Therapeutic hypothermia
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/j.ejpn.2020.04.003

Neurodevelopmental follow-up in Neonatal Hypoxic Ischaemic Encephalopathy (HIE) typically focusses on major neuromotor (cerebral palsy, CP) and severe cognitive impairment. Outcomes in those without major neuromotor impairment are less well explored. To examine behavioural, cognitive and neurological outcomes after neonatal HIE, in a clinical cohort of children without CP, at age 2 years. Clinical routine outcome data from children admitted to a tertiary centre with neonatal HIE for hypothermia treatment between 05/08/09–30/05/2016. Children were assessed for neuromotor status – particularly minor neurological signs (MNS), with Bayley Scales of Infant and Toddler Development III (Bayley III) or Ages and Stages Questionnaire-3 (ASQ), Child Behavior Checklist 1.5–5 (CBCL), Quantitative Checklist for Autism in Toddlers (Q-CHAT). Of 107 children, 75.5% had normal neurology, 12.1% CP, 12.1% MNS. Children with CP were excluded from analyses. For those without CP, Bayley-III scores were in the average range for the majority; mild cognitive delay observed in 5%, 4.2% language, 1.3% motor development; severe delay in 1.3% for cognitive, 4.2% for language. More than in the normative population scored in clinical ranges for CBCL externalising, sleep, and other problems. No significant difference was seen for Q-CHAT. Children with MNS were significantly more likely to have impaired Bayley-III scores, parent-reported internalising, sleep, and other problems. In this clinical cohort, the majority of children had favourable outcome at 2 years. However, children with MNS were at risk for cognitive and behavioural difficulties and will benefit from enhanced clinical follow-up and support. •The majority of children without Cerebral Palsy have normal cognitive development.•More children than expected have externalising behaviour and sleep difficulties.•Minor neurological signs pose a risk for impaired neurodevelopment and behaviour.•Survivors of HIE with minor neurological signs need enhanced follow-up.