The influence of thyroid autoimmunity on pregnancy outcome in infertile women: a prospective study

• Published in: ENDOCRINE JOURNAL 2020, Vol.67(8), pp.859-868
• Main Authors: Inagaki, Yuko, Takeshima, Ken, Nishi, Masahiro, Ariyasu, Hiroyuki, Doi, Asako, Kurimoto, Chiaki, Uraki, Shinsuke, Morita, Shuhei, Furukawa, Yasushi, Inaba, Hidefumi, Iwakura, Hiroshi, Shimokawa, Toshio, Utsunomiya, Tomoko, Akamizu, Takashi
• Format: Article
• Language: English
• Subjects: Assisted reproductive technology; Autoimmunity; Fertility; Graves' disease; Hypothyroidism; In vitro fertilization; Infertility; Iodide peroxidase; Miscarriage; Pregnancy; Premature birth; Reproductive technologies; Risk factors; Subclinical hypothyroidism; Thyroglobulin; Thyroid; Thyroid autoimmunity; Thyroid gland; Thyroid-stimulating hormone; Thyroxine
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.EJ19-0604

Thyroid dysfunction and thyroid autoimmunity (TAI) have been reported to be linked to infertility, pregnancy loss and preterm birth. Infertile women undergoing assisted reproductive technology are recommended to maintain thyroid stimulating hormone (TSH) levels below 2.5 μIU/mL. It is unclear, however, whether levothyroxine (L-T4) treatment decreases the effects of TAI on fertility and pregnancy outcome in infertile women. We therefore aimed to clarify the influence of TAI on pregnancy undergoing L-T4 treatment for hypothyroidism. Prospectively recruited to this study were the 595 infertile women who visited the Utsunomiya Ladies Clinic between January 2013 and December 2015. Five patients with Graves’ disease were excluded. Clinical profiles of 590 women were as follows: proportion of SCH = 19.6%, thyroid peroxidase antibody (TPOAb) positivity = 10.4%, and thyroglobulin antibody (TgAb) positivity = 15.1%. Fertility was not affected by any thyroid-associated factors. Regarding pregnancy outcomes, TPOAb titers were significantly higher in women who had miscarriage than in those progressed to delivery (46.4 ± 114.1 vs. 18.9 ± 54.6 IU/mL, p = 0.039), notably in those undergoing intrauterine insemination (p = 0.046) and in vitro fertilization (p = 0.023). Multivariate logistic regression analysis revealed that higher age (odds ratio 26.4, p < 0.001) and higher TPOAb titer (odds ratio 11.8, p = 0.043) were risk factors for miscarriage. Higher TPOAb titer should be considered as one of the risk factors for miscarriage in infertile women, even if they have been treated with L-T4 for hypothyroidism.