Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder

Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-ep...

Full description

Saved in:
Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2021-04, Vol.271 (3), p.475-485
Main Authors: Tian, Haihua, Li, Guangxue, Xu, Guoan, Liu, Jimeng, Wan, Xiaohan, Zhang, Jiao, Xie, Shuguang, Cheng, Jia, Gao, Shugui
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents - administration & dosage
Case-Control Studies
Cognitive ability
Cognitive Dysfunction - blood
Cognitive Dysfunction - etiology
Cognitive Dysfunction - immunology
Cognitive Dysfunction - physiopathology
Combined Modality Therapy
Cross-Sectional Studies
Cytokines
Cytokines - blood
Depressive Disorder, Major - blood
Depressive Disorder, Major - complications
Depressive Disorder, Major - immunology
Depressive Disorder, Major - therapy
Electroconvulsive therapy
Electroconvulsive Therapy - adverse effects
Female
Humans
Inflammasomes
Inflammasomes - blood
Inflammation
Interleukin 18
Interleukin-18 - blood
Male
Medicine
Medicine & Public Health
Memory
Memory Disorders - blood
Memory Disorders - etiology
Memory Disorders - immunology
Memory Disorders - physiopathology
Mental depression
Middle Aged
Neurosciences
NF-kappaB-Inducing Kinase
NF-κB protein
NLR Family, Pyrin Domain-Containing 3 Protein - blood
Original Paper
Outcome Assessment, Health Care
Peripheral blood
Protein Serine-Threonine Kinases - blood
Psychiatry
Serum levels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-episode, drug-free MDD patients and 40 healthy controls were recruited. MECT was started with antidepressant treatment at a stable initial dose. The Wechsler Memory Scale (WMS) and Hamilton Rating Scale for Depression 17 (HRSD-17) were used to assess the cognitive function. MDD patients were divided into the memory impairment group (WMS 
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-020-01128-9