Stepwise Disease Progression Model of Subsolid Lung Adenocarcinoma with Cystic Airspaces

• Published in: Annals of surgical oncology 2020-10, Vol.27 (11), p.4394-4403
• Main Authors: Jung, Woohyun, Cho, Sukki, Yum, Sungwon, Chung, Jin-Haeng, Lee, Kyung Won, Kim, Kwhanmien, Lee, Choon Taek, Jheon, Sanghoon
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - diagnostic imaging; Adenocarcinoma of Lung - pathology; Computed tomography; Cysts - diagnostic imaging; Cysts - pathology; Disease Progression; Humans; Lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - pathology; Medicine; Medicine & Public Health; Multivariate analysis; Neoplasm Staging; Oncology; Patients; Retrospective Studies; Surgery; Surgical Oncology; Thoracic Oncology
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-020-08508-4

Objectives Subsolid lung adenocarcinoma with cystic airspaces (LACA) is a unique manifestation of lung cancer. This study was conducted to establish a radiologic disease progression model of LACA and to explore its association with the clinical course and clinicopathologic features of LACA. Materials and Methods Sixty patients with LACA who underwent surgery at our center between 2004 and 2017 were retrospectively reviewed. The morphological changes of LACA over time on 98 serial computed tomography scans from 27 of 60 patients were tracked to establish a radiologic disease progression model. Associations between this model and the clinicopathologic characteristics of LACA were investigated. Results The following stepwise progression model of LACA was developed: in phase I, cystic airspaces (CAs) appear in the middle of non-solid nodules; in phase II, the CAs grow; in phase III, a solid component appears on the border of the CAs; and in phase IV, the solid component gradually surrounds the CAs and becomes thicker, and the CAs shrink. In total, 10 (17%), 33 (55%), and 17 (28%) LACA patients were classified as belonging to phases II, III, and IV at the time of surgery, respectively. More advanced phases were associated with higher pathologic T and N staging, lymphovascular invasion, visceral pleural invasion, spread through air spaces, and solid/micropapillary subtype. In the multivariate analysis, our model demonstrated a good discrimination capability for cancer recurrence risk. Conclusions The stepwise disease progression model of LACA based on radiologic findings developed in this study represented its natural clinical course and clinicopathologic features well.