Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment

Background: Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia. Objective: We aimed to reevaluate the existing uncert...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2020-01, Vol.75 (3), p.1061-1069
Main Authors: García-García-Patino, Rosalía, Benito-León, Julián, Mitchell, Alex J., Pastorino-Mellado, Damián, García García, Ricardo, Ladera-Fernández, Valentina, Vicente-Villardón, Jose Luis, Perea-Bartolomé, María Victoria, Cacho, Jesús
Format: Article
Language:English
Subjects:
Activities of daily living
Activities of Daily Living - psychology
Aged
Alzheimer's disease
Amnesia - complications
Amnesia - diagnosis
Amnesia - psychology
Cognitive ability
Cognitive Dysfunction - complications
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - psychology
Dementia
Dementia disorders
Domains
Executive Function
Female
Humans
Impairment
Male
Memory
Mental Status and Dementia Tests
Neurodegenerative diseases
Regression analysis
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Summary:Background: Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia. Objective: We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI. Methods: Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer’s disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance. Results: Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p 
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-191263