Serum albumin level is associated with the severity of neurological dysfunction of NMOSD patients

• Published in: Multiple sclerosis and related disorders 2020-08, Vol.43, p.102130-102130, Article 102130
• Main Authors: Yao, Xiao-Ying, Wu, Yi-Fan, Gao, Mei-Chun, Hong, Rong-Hua, Ding, Jie, Hao, Yong, Zhang, Ying, Guan, Yang-Tai
• Format: Article
• Language: English
• Subjects: Cytokines; Humans; Interleukin -33; Interleukins; Neuromyelitis Optica - blood; Neuromyelitis Optica - physiopathology; Neuromyelitis optica spectrum disorders; Prognosis; Serum Albumin; Severity of Illness Index
• ISSN: 2211-0348; 2211-0356
• DOI: 10.1016/j.msard.2020.102130

•Serum albumin (SA) negatively correlated with EDSS in acute phase of NMOSD.•A low SA level was an independent factor of severe disability in acute attacks.•Serum albumin negatively associated with IL-33 in acute phase of NMOSD.•SA may play a protective role in NMOSD partly through its interaction with IL-33. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system. Serum albumin (SA) has antioxidant, immunomodulatory and anti-inflammatory effects. However, the roles of SA in NMOSD have not been studied. The current study aimed to clarify the association of SA with disease severity and prognosis in NMOSD patients. Serum levels of albumin were measured by Bromcresol Green method. Serum level measurements of interleukins were performed using enzyme-linked immunoassay (ELISA) method. Of all the 130 NMOSD patients, 96 patients were in the acute phase while 34 patients were in the remission phase of disease at the time of sampling. SA concentration was significantly correlated with EDSS score in patients in the acute phase but not in remission phase (r = - 0.388, p