Changes in the severity of gastric mucosal inflammation associated with Helicobacter pylori in humans coinfected with  intestinal helminths

• Published in: Indian journal of gastroenterology 2020-04, Vol.39 (2), p.186-195
• Main Authors: Fuenmayor-Boscán, Alisbeth, Hernández-Rincón, Ileana, Arismendi-Morillo, Gabriel, Mengual, Edgardo, Rivero, Zulbey, Romero, Gisela, Lizarzábal, Maribel, Álvarez-Mon, Melchor
• Format: Article
• Language: English
• Subjects: Gastroenterology; Hepatology; Medicine; Medicine & Public Health; Original Article
• ISSN: 0254-8860; 0975-0711
• DOI: 10.1007/s12664-020-01023-0

Background Though a few studies in animal models suggest that intestinal helminths (IH) favorably affect evolution of gastritis associated with Helicobacter pylori ( H. pylori ) the studies supporting this concept in humans are only a few and are based on serological data. Methods To evaluate the possible influence of IH on the human gastric mucosa, three groups of Venezuelan adults with gastropathy (endoscopically diagnosed) were studied: H. pylori −/IH− ( n  = 17), H. pylori +/IH− ( n  = 18), and H. pylori +/IH+ ( n  = 11). Histological analysis (hematoxylin-eosin) and immunohistochemical staining (peroxidase) for cytokines interleukin-1beta (IL-1β), tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin 4 (IL-4) were undertaken in gastric antral biopsies. Results Expression of the four cytokines was detected in all individuals in varying degrees, but proinflammatory cytokines were expressed in a higher degree in the H. pylori +/IH− group, mainly IL-1β (Th1-dominant immune response), associated with a higher degree of both histological inflammation and gastric cancer risk index (GCRI), as compared to the H. pylori −/IH− group. In contrast, an increased expression of IL-4 and a reduced expression of proinflammatory cytokines (Th2-dominant response), plus the tendency to a lower degree of mononuclear infiltration, mucosal atrophy in gastric corpus, and GCRI, were evidenced in the coinfected group. Conclusions The findings of the present study is perhaps the first histological evidence of a possible modulatory effect of IH on the gastric mucosal inflammatory response due to  H. pylori infection in humans.