A systematic review of guidelines for lymphedema and the need for contemporary intersocietal guidelines for the management of lymphedema

• Published in: Journal of vascular surgery. Venous and lymphatic disorders (New York, NY) NY), 2020-07, Vol.8 (4), p.676-684
• Main Authors: O'Donnell, Thomas F., Allison, Geneve M., Iafrati, Mark D.
• Format: Article
• Language: English
• Subjects: Consensus; Edema; Evidence-Based Medicine - standards; Guidelines; Humans; Lymphedema; Lymphedema - diagnosis; Lymphedema - epidemiology; Lymphedema - therapy; Practice Guidelines as Topic - standards; Systematic review; Treatment Outcome
• ISSN: 2213-333X; 2213-3348
• DOI: 10.1016/j.jvsv.2020.03.006

Lymphedema (LED) affects an estimated 35 million patients in the United States and a staggering 140,200 million people worldwide, yet LED is the forgotten vascular disease. Whereas the diagnosis and treatment of arterial and venous diseases have been strengthened by the development of clinical practice guidelines (CPGs), few CPGs are available for LED. Moreover, for CPGs to have their greatest impact, they should be both of high quality and developed using the most rigorous evidence-based methods. We performed a systematic review of the available CPGs for LED, which were assessed for breadth of content and methodologic strength. A literature search was conducted from National Guideline Clearinghouse (www.guidelines.gov), BMJ Clinical Evidence (http://clinicalevidence.bmj.com), and National Institute for Health and Care Excellence (http://www.nice.org.uk) as well as from MEDLINE and Google, which selected 245 documents. After a horizon scan that identified 13 potential CPGs, 4 satisfied the criteria for LED. These were analyzed for inclusion of key elements of diagnosis and treatment. A horizon scan (abstract review) of the 245 documents identified 10 potential CPGs. Of the 10 documents, 6 claimed to be CPGs, but 2 were limited in scope (rehabilitation or compression only), 2 were consensus statements, 1 was a position statement, and 1 was a systematic review. This process yielded four CPGs: Lymphedema Framework Best Practice for the Management of Lymphedema; Japanese Lymphedema Study Group—A Practice Guideline for the Management of Lymphedema; Clinical Resource Efficiency Support Team Guidelines for the Diagnosis, Assessment and Management of Lymphedema; and Guidelines of the American Venous Forum. Only one of four CPGs was based on a contemporary systematic review (2016 end date of references), whereas the remainder had older systematic reviews (end dates of 2005, 2007, and 2007). Several areas of contemporary diagnosis, treatment, and monitoring of LED were absent. This systematic review of available LED CPGs demonstrates a limited number of guidelines. The four CPGs identified lack contemporary references while demonstrating low overall study quality. Therefore, it is imperative for our vascular societies to develop contemporary high-quality evidence-based CPGs for LED, as they have for other vascular diseases.