Oxygen‐sensing mechanisms in cells

The importance of oxygen for the survival of multicellular and aerobic organisms is well established and documented. Over the years, increased knowledge of its use for bioenergetics has placed oxygen at the centre of research on mitochondria and ATP‐generating processes. Understanding the molecular...

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Bibliographic Details
Published in:The FEBS journal 2020-09, Vol.287 (18), p.3888-3906
Main Authors: Wilson, James W., Shakir, Dilem, Batie, Michael, Frost, Mark, Rocha, Sonia
Format: Article
Language:English
Subjects:
2‐OG dioxygenases
Adenosine Triphosphate - metabolism
Animals
Bioenergetics
chromatin
Dioxygenases - genetics
Dioxygenases - metabolism
Gene expression
HIF
Humans
hydroxylation
hypoxia
JmjC histone demethylases
Jumonji Domain-Containing Histone Demethylases - genetics
Jumonji Domain-Containing Histone Demethylases - metabolism
Mitochondria
Mitochondria - metabolism
Models, Biological
Molecular modelling
NF‐kappaB
Oxygen
Oxygen - metabolism
Oxygen tension
PHDs
Signal Transduction
Signaling
transcription
Transcription, Genetic
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Summary:The importance of oxygen for the survival of multicellular and aerobic organisms is well established and documented. Over the years, increased knowledge of its use for bioenergetics has placed oxygen at the centre of research on mitochondria and ATP‐generating processes. Understanding the molecular mechanisms governing cellular oxygen sensing and response has allowed for the discovery of novel pathways oxygen is involved in, culminating with the award of the Nobel Prize for Medicine and Physiology in 2019 to the pioneers of this field, Greg Semenza, Peter Ratcliffe and William Kaelin. However, it is now beginning to be appreciated that oxygen can be a signalling molecule involved in a vast array of molecular processes, most of which impinge on gene expression control. This review will focus on the knowns and unknowns of oxygen as a signalling molecule, highlighting the role of 2‐oxoglutarate‐dependent dioxygenases as central players in the cellular response to deviations in oxygen tension. Understanding the molecular mechanisms governing cellular oxygen sensing and response has allowed for the discovery of novel pathways oxygen is involved in. Oxygen can be a signalling molecule involved in a vast array of molecular processes, most of which impinge on gene expression control. These include control of HIF, regulation of chromatin and transcription, regulation of cell fate and translation.
ISSN:1742-464X
1742-4658
DOI:10.1111/febs.15374