Severe vitamin D deficiency in preterm infants: possibly no association with clinical outcomes?

The primary objective of this study was to compare clinical outcomes of very low birth weight (VLBW) infants with 25-hydroxy vitamin D [25(OH)D] levels 25 nmol/l. The secondary objective was to evaluate umbilical cord vitamin D as a risk factor for respiratory distress syndrome (RDS) in preterm infa...

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Published in:The journal of maternal-fetal & neonatal medicine 2022-04, Vol.35 (8), p.1562-1570
Main Authors: Matejek, Tomas, Zemankova, Jana, Malakova, Jana, Cermakova, Eva, Skalova, Sylva, Palicka, Vladimir
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
Adult
clinical outcome
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
prematurity
preterm infants
Prospective Studies
Vitamin D
Vitamin D Deficiency - complications
Vitamins
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Summary:The primary objective of this study was to compare clinical outcomes of very low birth weight (VLBW) infants with 25-hydroxy vitamin D [25(OH)D] levels 25 nmol/l. The secondary objective was to evaluate umbilical cord vitamin D as a risk factor for respiratory distress syndrome (RDS) in preterm infants. We examined 25(OH)D levels in umbilical cord blood and in infants' serum at discharge from the neonatal intensive care unit. We evaluated the associations between severe vitamin D deficiency and various laboratory findings and clinical outcomes. Eighty one infants with birth weight less than 1500 g met the entry criteria for this study and were divided to groups according to umbilical cord blood vitamin D [Group A: 25(OH)D  25 nmol/l; 10 ng/ml]. Overall, 81.5% of the infants had a 25(OH)D level
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2020.1762560