Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents

The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus 2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a pressing global need for effective antiviral therapies against it. COVID-19 disease pathogenesis is characterized by an in...

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Bibliographic Details
Published in:Emerging microbes & infections 2020-01, Vol.9 (1), p.1397-1406
Main Authors: Gelman, Ram, Bayatra, Areej, Kessler, Asa, Schwartz, Asaf, Ilan, Yaron
Format: Article
Language:English
Subjects:
ACE
Algorithms
Animals
Antiviral Agents - pharmacology
Betacoronavirus - drug effects
Betacoronavirus - genetics
Betacoronavirus - physiology
Coronavirus
Coronavirus Infections - drug therapy
Coronavirus Infections - genetics
Coronavirus Infections - immunology
Coronavirus Infections - virology
Coronaviruses
COVID-19
DPP4
Drug Resistance, Viral
Humans
Pandemics
Pneumonia, Viral - drug therapy
Pneumonia, Viral - genetics
Pneumonia, Viral - immunology
Pneumonia, Viral - virology
receptors
Receptors, Virus - antagonists & inhibitors
Receptors, Virus - genetics
Receptors, Virus - immunology
Review
SARS-COV-2
Severe acute respiratory syndrome coronavirus 2
treatment
viral resistance
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Summary:The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus 2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a pressing global need for effective antiviral therapies against it. COVID-19 disease pathogenesis is characterized by an initial virus-mediated phase, followed by inappropriate hyperactivation of the immune system leading to organ damage. Targeting of the SARS-CoV-2 viral receptors is being explored as a therapeutic option for these patients. In this paper, we summarize several potential receptors associated with the infectivity of SARS-CoV-2 and discuss their association with the immune-mediated inflammatory response. The potential for the development of resistance towards antiviral drugs is also presented. An algorithm-based platform to improve the efficacy of and overcome resistance to viral receptor blockers through the introduction of personalized variability is described. This method is designed to ensure sustained antiviral effectiveness when using SARS-CoV-2 receptor blockers.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1776161