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Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment
The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RF...
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| Published in: | Heart and vessels 2020-11, Vol.35 (11), p.1518-1526 |
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| container_issue | 11 |
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| container_title | Heart and vessels |
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| creator | Ohashi, Hirofumi Takashima, Hiroaki Ando, Hirohiko Suzuki, Akihiro Sakurai, Shinichiro Nakano, Yusuke Sawada, Hiroaki Fujimoto, Masanobu Suzuki, Wataru Shimoda, Masahiro Tajima, Atomu Waseda, Katsuhisa Ohashi, Wataru Amano, Tetsuya |
| description | The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RFR directly with FFR and clarify the clinical feasibility of RFR as a unique non-hyperemic index in evaluating the cardiac cycle. The diagnostic performance of RFR was compared with FFR using an automated online calculation software. A total of 156 consecutive patients with 220 intermediate lesions were enrolled. RFR showed significant correlation with FFR (
r
= 0.774,
p
|
| doi_str_mv | 10.1007/s00380-020-01638-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2410705319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2450403022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-1e39bfe572e6952432b80d8dd6669bc86c109e7c20b189fddda2dddbf6cfcf213</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhYnROD2jL-DCkLhxg16goYql6fgzySRudE0o6jIyoagWqibW20vboyYuXPCT8H2HmxxCXnB4wwG6txVA9sBAtMW17Jl6RHZcc8WE6uRjsgPDgfVSdBfkstY7AK4MN0_JhRQKNO_ljmyHFHP0LtGArsYhprhsdA60YF1ivqVhTYn5zSekxS1xpq5SR9ccv69I85zZt-2IBafoacwj_ji5Md-3rHtscvbNyS0-YW2XZlesdcK8PCNPgksVnz-cV-Trh_dfDp_YzeeP14d3N8wrvl8YR2mGgKoTqI0SeymGHsZ-HLXWZvC99hwMdl7AwHsTxnF0om1D0D74ILi8Iq_Puccyt5nrYqdYPabkMs5rtWLPoQMluWnoq3_Qu3ktbfoTpWAPEoRolDhTvsy1Fgz2WOLkymY52FMx9lyMbcXYX8VY1aSXD9HrMOH4R_ndRAPkGajtKd9i-fv3f2J_Al7cmuU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2450403022</pqid></control><display><type>article</type><title>Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment</title><source>Springer Nature</source><creator>Ohashi, Hirofumi ; Takashima, Hiroaki ; Ando, Hirohiko ; Suzuki, Akihiro ; Sakurai, Shinichiro ; Nakano, Yusuke ; Sawada, Hiroaki ; Fujimoto, Masanobu ; Suzuki, Wataru ; Shimoda, Masahiro ; Tajima, Atomu ; Waseda, Katsuhisa ; Ohashi, Wataru ; Amano, Tetsuya</creator><creatorcontrib>Ohashi, Hirofumi ; Takashima, Hiroaki ; Ando, Hirohiko ; Suzuki, Akihiro ; Sakurai, Shinichiro ; Nakano, Yusuke ; Sawada, Hiroaki ; Fujimoto, Masanobu ; Suzuki, Wataru ; Shimoda, Masahiro ; Tajima, Atomu ; Waseda, Katsuhisa ; Ohashi, Wataru ; Amano, Tetsuya</creatorcontrib><description>The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RFR directly with FFR and clarify the clinical feasibility of RFR as a unique non-hyperemic index in evaluating the cardiac cycle. The diagnostic performance of RFR was compared with FFR using an automated online calculation software. A total of 156 consecutive patients with 220 intermediate lesions were enrolled. RFR showed significant correlation with FFR (
r
= 0.774,
p
< 0.001). RFR systole and RFR diastole did also with FFR (
r
= 0.918,
p
< 0.001, and
r
= 0.733,
p
< 0.001, respectively). With FFR < 0.80 as a reference standard, RFR showed good diagnostic accuracy (DA: 80.5%), similar DA between RFR systole and RFR diastole (79.6% and 87.5%,
p
= 0.58, respectively), and good DA in any lesion locations, especially in non-left anterior descending coronary artery (LAD) lesions (73.7% and 87.6% for LAD vs. non-LAD,
p
< 0.05, respectively). RFR is a feasible and reliable non-hyperemic index regardless of the difference in cardiac cycle in evaluating physiological lesion severity in daily practice.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-020-01638-5</identifier><identifier>PMID: 32506183</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Aged, 80 and over ; Biomedical Engineering and Bioengineering ; Cardiac Catheterization ; Cardiac Surgery ; Cardiology ; Coronary artery ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - physiopathology ; Coronary Circulation ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - physiopathology ; Cycle ratio ; Diagnostic systems ; Diastole ; Feasibility ; Feasibility Studies ; Female ; Fractional Flow Reserve, Myocardial ; Heart ; Humans ; Hyperemia - physiopathology ; Ischemia ; Lesions ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial ischemia ; Original Article ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Systole ; Vascular Surgery</subject><ispartof>Heart and vessels, 2020-11, Vol.35 (11), p.1518-1526</ispartof><rights>Springer Japan KK, part of Springer Nature 2020</rights><rights>Springer Japan KK, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-1e39bfe572e6952432b80d8dd6669bc86c109e7c20b189fddda2dddbf6cfcf213</citedby><cites>FETCH-LOGICAL-c514t-1e39bfe572e6952432b80d8dd6669bc86c109e7c20b189fddda2dddbf6cfcf213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32506183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohashi, Hirofumi</creatorcontrib><creatorcontrib>Takashima, Hiroaki</creatorcontrib><creatorcontrib>Ando, Hirohiko</creatorcontrib><creatorcontrib>Suzuki, Akihiro</creatorcontrib><creatorcontrib>Sakurai, Shinichiro</creatorcontrib><creatorcontrib>Nakano, Yusuke</creatorcontrib><creatorcontrib>Sawada, Hiroaki</creatorcontrib><creatorcontrib>Fujimoto, Masanobu</creatorcontrib><creatorcontrib>Suzuki, Wataru</creatorcontrib><creatorcontrib>Shimoda, Masahiro</creatorcontrib><creatorcontrib>Tajima, Atomu</creatorcontrib><creatorcontrib>Waseda, Katsuhisa</creatorcontrib><creatorcontrib>Ohashi, Wataru</creatorcontrib><creatorcontrib>Amano, Tetsuya</creatorcontrib><title>Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RFR directly with FFR and clarify the clinical feasibility of RFR as a unique non-hyperemic index in evaluating the cardiac cycle. The diagnostic performance of RFR was compared with FFR using an automated online calculation software. A total of 156 consecutive patients with 220 intermediate lesions were enrolled. RFR showed significant correlation with FFR (
r
= 0.774,
p
< 0.001). RFR systole and RFR diastole did also with FFR (
r
= 0.918,
p
< 0.001, and
r
= 0.733,
p
< 0.001, respectively). With FFR < 0.80 as a reference standard, RFR showed good diagnostic accuracy (DA: 80.5%), similar DA between RFR systole and RFR diastole (79.6% and 87.5%,
p
= 0.58, respectively), and good DA in any lesion locations, especially in non-left anterior descending coronary artery (LAD) lesions (73.7% and 87.6% for LAD vs. non-LAD,
p
< 0.05, respectively). RFR is a feasible and reliable non-hyperemic index regardless of the difference in cardiac cycle in evaluating physiological lesion severity in daily practice.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Catheterization</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Cycle ratio</subject><subject>Diagnostic systems</subject><subject>Diastole</subject><subject>Feasibility</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Heart</subject><subject>Humans</subject><subject>Hyperemia - physiopathology</subject><subject>Ischemia</subject><subject>Lesions</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial ischemia</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Severity of Illness Index</subject><subject>Systole</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhYnROD2jL-DCkLhxg16goYql6fgzySRudE0o6jIyoagWqibW20vboyYuXPCT8H2HmxxCXnB4wwG6txVA9sBAtMW17Jl6RHZcc8WE6uRjsgPDgfVSdBfkstY7AK4MN0_JhRQKNO_ljmyHFHP0LtGArsYhprhsdA60YF1ivqVhTYn5zSekxS1xpq5SR9ccv69I85zZt-2IBafoacwj_ji5Md-3rHtscvbNyS0-YW2XZlesdcK8PCNPgksVnz-cV-Trh_dfDp_YzeeP14d3N8wrvl8YR2mGgKoTqI0SeymGHsZ-HLXWZvC99hwMdl7AwHsTxnF0om1D0D74ILi8Iq_Puccyt5nrYqdYPabkMs5rtWLPoQMluWnoq3_Qu3ktbfoTpWAPEoRolDhTvsy1Fgz2WOLkymY52FMx9lyMbcXYX8VY1aSXD9HrMOH4R_ndRAPkGajtKd9i-fv3f2J_Al7cmuU</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Ohashi, Hirofumi</creator><creator>Takashima, Hiroaki</creator><creator>Ando, Hirohiko</creator><creator>Suzuki, Akihiro</creator><creator>Sakurai, Shinichiro</creator><creator>Nakano, Yusuke</creator><creator>Sawada, Hiroaki</creator><creator>Fujimoto, Masanobu</creator><creator>Suzuki, Wataru</creator><creator>Shimoda, Masahiro</creator><creator>Tajima, Atomu</creator><creator>Waseda, Katsuhisa</creator><creator>Ohashi, Wataru</creator><creator>Amano, Tetsuya</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment</title><author>Ohashi, Hirofumi ; Takashima, Hiroaki ; Ando, Hirohiko ; Suzuki, Akihiro ; Sakurai, Shinichiro ; Nakano, Yusuke ; Sawada, Hiroaki ; Fujimoto, Masanobu ; Suzuki, Wataru ; Shimoda, Masahiro ; Tajima, Atomu ; Waseda, Katsuhisa ; Ohashi, Wataru ; Amano, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-1e39bfe572e6952432b80d8dd6669bc86c109e7c20b189fddda2dddbf6cfcf213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Catheterization</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Cycle ratio</topic><topic>Diagnostic systems</topic><topic>Diastole</topic><topic>Feasibility</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fractional Flow Reserve, Myocardial</topic><topic>Heart</topic><topic>Humans</topic><topic>Hyperemia - physiopathology</topic><topic>Ischemia</topic><topic>Lesions</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial ischemia</topic><topic>Original Article</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Severity of Illness Index</topic><topic>Systole</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohashi, Hirofumi</creatorcontrib><creatorcontrib>Takashima, Hiroaki</creatorcontrib><creatorcontrib>Ando, Hirohiko</creatorcontrib><creatorcontrib>Suzuki, Akihiro</creatorcontrib><creatorcontrib>Sakurai, Shinichiro</creatorcontrib><creatorcontrib>Nakano, Yusuke</creatorcontrib><creatorcontrib>Sawada, Hiroaki</creatorcontrib><creatorcontrib>Fujimoto, Masanobu</creatorcontrib><creatorcontrib>Suzuki, Wataru</creatorcontrib><creatorcontrib>Shimoda, Masahiro</creatorcontrib><creatorcontrib>Tajima, Atomu</creatorcontrib><creatorcontrib>Waseda, Katsuhisa</creatorcontrib><creatorcontrib>Ohashi, Wataru</creatorcontrib><creatorcontrib>Amano, Tetsuya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohashi, Hirofumi</au><au>Takashima, Hiroaki</au><au>Ando, Hirohiko</au><au>Suzuki, Akihiro</au><au>Sakurai, Shinichiro</au><au>Nakano, Yusuke</au><au>Sawada, Hiroaki</au><au>Fujimoto, Masanobu</au><au>Suzuki, Wataru</au><au>Shimoda, Masahiro</au><au>Tajima, Atomu</au><au>Waseda, Katsuhisa</au><au>Ohashi, Wataru</au><au>Amano, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>35</volume><issue>11</issue><spage>1518</spage><epage>1526</epage><pages>1518-1526</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RFR directly with FFR and clarify the clinical feasibility of RFR as a unique non-hyperemic index in evaluating the cardiac cycle. The diagnostic performance of RFR was compared with FFR using an automated online calculation software. A total of 156 consecutive patients with 220 intermediate lesions were enrolled. RFR showed significant correlation with FFR (
r
= 0.774,
p
< 0.001). RFR systole and RFR diastole did also with FFR (
r
= 0.918,
p
< 0.001, and
r
= 0.733,
p
< 0.001, respectively). With FFR < 0.80 as a reference standard, RFR showed good diagnostic accuracy (DA: 80.5%), similar DA between RFR systole and RFR diastole (79.6% and 87.5%,
p
= 0.58, respectively), and good DA in any lesion locations, especially in non-left anterior descending coronary artery (LAD) lesions (73.7% and 87.6% for LAD vs. non-LAD,
p
< 0.05, respectively). RFR is a feasible and reliable non-hyperemic index regardless of the difference in cardiac cycle in evaluating physiological lesion severity in daily practice.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>32506183</pmid><doi>10.1007/s00380-020-01638-5</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biomedical Engineering and Bioengineering Cardiac Catheterization Cardiac Surgery Cardiology Coronary artery Coronary Artery Disease - diagnosis Coronary Artery Disease - physiopathology Coronary Circulation Coronary Stenosis - diagnostic imaging Coronary Stenosis - physiopathology Cycle ratio Diagnostic systems Diastole Feasibility Feasibility Studies Female Fractional Flow Reserve, Myocardial Heart Humans Hyperemia - physiopathology Ischemia Lesions Male Medicine Medicine & Public Health Middle Aged Myocardial ischemia Original Article Predictive Value of Tests Prognosis Prospective Studies Reproducibility of Results Severity of Illness Index Systole Vascular Surgery |
| title | Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment |
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