Urinary biomarkers of inflammation and tissue remodeling may predict bladder dysfunction in patients with benign prostatic hyperplasia

• Published in: International urology and nephrology 2020-11, Vol.52 (11), p.2051-2057
• Main Authors: de Conti, Paulo Sajovic, Barbosa, João Arthur Brunhara Alves, Reis, Sabrina Thalita, Viana, Nayara I., Gomes, Cristiano Mendes, Borges, Leonardo, Nunes, Marco, Nahas, William C., Srougi, Miguel, Antunes, Alberto Azoubel
• Format: Article
• Language: English
• Subjects: Biomarkers; Chromium; Creatinine; Epidermal growth factor; Genital diseases; Growth factors; Hyperplasia; Interleukin 6; Interstitial collagenase; Matrix metalloproteinase; Medicine; Medicine & Public Health; Metalloproteinase; Monocyte chemoattractant protein 1; Monocytes; Nephrology; Nerve growth factor; Patients; Surgery; Urology; Urology - Original Paper
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-020-02537-4

Purpose To evaluate the expression of urinary biomarkers of inflammation and tissue remodeling in patients with BPH undergoing surgery and evaluate the association of biomarkers with postoperative urodynamic outcomes Materials and methods We analyzed urine samples from 71 patients treated with TURP from 2011 to 2017. Urinary levels of epidermal growth factor (EGF), matrix-metalloproteinase-1 (MMP-1), interleukin-6 (IL-6), nerve growth factor (NGF) and monocyte-chemoattractant protein-1 (MCP-1) (by commercial ELISA kit) were measured, adjusted by urinary creatinine (Cr) and analyzed according to patients clinical and urodynamic characteristics (baseline and 12-month postoperative urodynamic) Results MMP-1/Cr levels were significantly higher among subjects with higher detrusor pressure on preoprative urodynamic. MCP-1/Cr levels were significantly higher amongs subjects with preoperative DO. Preoperative levels of NGF/Cr (0.13 vs 0.08, p  = 0.005) and MMP-1/Cr (0.11 vs 0.04, p  = 0.021) were predictors of persistent DO 12 months after surgery. The following factors were shown to be useful for predicting the persistence of DO in the postoperative period: NGF/Cr, with an AUC of 0.77 (95% CI 0.62–0.92) ( p  = 0.006), and MMP-1/Cr, with an AUC of 0.72 (95% CI 0.56–0.88) ( p  = 0.022). Conclusions MMP-1/Cr was associated with higher detrusor pressure and MCP-1/CR with DO. NGF/Cr and MMP-1/Cr were shown to be predictors of persistent postoperative DO.