Hemodynamic response to low-flow acute supplemental oxygen in idiopathic pulmonary fibrosis and elderly healthy subjects

•Hemodynamics is preserved during low-flow acute supplemental oxygen in elderly subjects.•Structural and functional damage in IPF patients deteriorate hemodynamics.•Low-flow acute supplemental oxygen further worsens hemodynamics in IPF patients.•A broad cardiopulmonary evaluation is needed before su...

Full description

Saved in:
Bibliographic Details
Published in:Heart & lung 2021-01, Vol.50 (1), p.197-205
Main Authors: Santiago-Fuentes, Laura Mercedes, González-Camarena, Ramón, Charleston-Villalobos, Sonia, Mejía-Ávila, Mayra Edith, Reulecke, Sina, Buendía-Roldán, Ivette, Gaitán-González, Mercedes Jatziri, Benítez-Valdez, Geovanni, Aljama-Corrales, Tomás
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cardiac Output
Cardiovascular function
Healthy Volunteers
Hemodynamics
Humans
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis - therapy
Impedance cardiography
Middle Aged
Oxygen
Supplemental oxygen
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Hemodynamics is preserved during low-flow acute supplemental oxygen in elderly subjects.•Structural and functional damage in IPF patients deteriorate hemodynamics.•Low-flow acute supplemental oxygen further worsens hemodynamics in IPF patients.•A broad cardiopulmonary evaluation is needed before supplemental oxygen is prescribed. Hemodynamic response to supplemental oxygen in idiopathic pulmonary fibrosis (IPF) is still not well known. To determine and compare the effect of low-flow acute supplemental oxygen on the hemodynamics of IPF patients and matched healthy subjects. Descriptive and comparative study in 20 IPF-patients and 19 Control-subjects, (60-80 years old) breathing ambient air followed by acute nasal low-flow (3 L/min) supplemental oxygen. Non-invasive methods were used during the supine position to evaluate oxygen saturation, heart rate, stroke volume index, cardiac output index, total peripheral resistance and arterial blood pressure. Breathing ambient air, IPF (vs. Control) presented lower values in stroke volume index (38.7 [29.4–43.2] vs. 45.4 [38.4–50.9] mL•kg-1•m2; p=0.009) and cardiac output index (2.484 [2.268 – 2.946] vs. 2.857 [2.628 – 3.054] L•min−1•m−2; p=0.028), with higher total peripheral resistance (1644 [1559–2076] vs. 1505 [1366–1784] dyne•s•cm−5; p=0.017). During supplemental oxygen (vs. ambient air), both groups increased oxygen saturation above 94% (p
ISSN:0147-9563
1527-3288
DOI:10.1016/j.hrtlng.2020.03.025