Clinically Actionable Strategies for Studying Neural Influences in Cancer

Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the stra...

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Bibliographic Details
Published in:Cancer cell 2020-07, Vol.38 (1), p.11-14
Main Authors: Demir, Ihsan Ekin, Reyes, Carmen Mota, Alrawashdeh, Wasfi, Ceyhan, Güralp O., Deborde, Sylvie, Friess, Helmut, Görgülü, Kivanc, Istvanffy, Rouzanna, Jungwirth, David, Kuner, Rohini, Maryanovich, Maria, Na’ara, Shorook, Renders, Simon, Saloman, Jami L., Scheff, Nicole N., Steenfadt, Hendrik, Stupakov, Pavel, Thiel, Vera, Verma, Divij, Yilmaz, Bengi Su, White, Ruth A., Wang, Timothy C., Wong, Richard J., Frenette, Paul S., Gil, Ziv, Davis, Brian M.
Format: Article
Language:English
Subjects:
Cancer Pain - diagnosis
Cancer Pain - physiopathology
Cancer Pain - therapy
Denervation - methods
Humans
Neoplasms - diagnosis
Neoplasms - physiopathology
Neoplasms - therapy
Nervous System - physiopathology
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Summary:Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic. Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2020.05.023