Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13

•Highly sensitive CXCL13 assay (Simoa) has higher accuracy than conventional ELISA.•Simoa assay facilitates early diagnosis of optic neuritis.•Intrathecal CXCL13 predicts development of MS in patients with acute optic neuritis. Elevation of CXCL13, a key regulator of B-cell recruitment in cerebrospi...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis and related disorders 2020-09, Vol.44, p.102281-102281, Article 102281
Main Authors: Olesen, M.N., Nilsson, A.C., Pihl-Jensen, G., Soelberg, K.K., Olsen, D.A., Brandslund, I., Lillevang, S.T., Madsen, J.S., Frederiksen, J.L., Asgari, N.
Format: Article
Language:English
Subjects:
Biomarkers
Cerebrospinal fluid
Chemokine CXCL13
Cohort Studies
CXCL13
Humans
Immunology
Multiple Sclerosis - diagnosis
Optic neuritis
Optic Neuritis - diagnosis
ROC Curve
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Highly sensitive CXCL13 assay (Simoa) has higher accuracy than conventional ELISA.•Simoa assay facilitates early diagnosis of optic neuritis.•Intrathecal CXCL13 predicts development of MS in patients with acute optic neuritis. Elevation of CXCL13, a key regulator of B-cell recruitment in cerebrospinal fluid (CSF) is implicated in multiple sclerosis (MS). to evaluate if measurement of CXCL13 using a highly sensitive assay is of value in acute optic neuritis (ON) patients for the prediction of later MS. CXCL13 was measured by Simoa in two independent treatment-naïve ON cohorts, a training cohort (TC, n = 33) originating from a population-based cohort, a validation cohort (VC, n = 30) consecutively collected following principles for population studies. Prospectively, 14/33 TC and 12/30 VC patients progressed to MS (MS-ON) while 19/33 TC and 18/30 VC patients, remained as isolated ON (ION). CXCL13 was detectable in all samples and were higher in ON compared with healthy controls (HC) (p = 0.012). In the TC, CSF levels in MS-ON were higher compared with ION patients and HC (p = 0.0001 and p
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2020.102281