Whole milk consumption is associated with lower risk of coronary artery calcification progression: evidences from the Multi-Ethnic Study of Atherosclerosis

Purpose Coronary artery calcification (CAC) progression is a strong predictor of cardiovascular disease (CVD) morbidity and mortality. However, the association between whole milk and CAC progression remains unknown. Recent studies highlighted beneficial effects of short chain fatty acids (SCFA) from...

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Bibliographic Details
Published in:European journal of nutrition 2021-03, Vol.60 (2), p.1049-1058
Main Authors: Ghosh, Sounak, He, Wanbing, Gao, Jingwei, Luo, Dongling, Wang, Jingfeng, Chen, Jie, Huang, Hui
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Body mass index
Calcification
Calcification (ectopic)
Cardiovascular diseases
Chemistry
Chemistry and Materials Science
Computed tomography
Coronary artery
Coronary vessels
Fatty acids
Milk
Morbidity
Nutrition
Original Contribution
Sex differences
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Summary:Purpose Coronary artery calcification (CAC) progression is a strong predictor of cardiovascular disease (CVD) morbidity and mortality. However, the association between whole milk and CAC progression remains unknown. Recent studies highlighted beneficial effects of short chain fatty acids (SCFA) from whole milk on CVD. In this study, we attempted to investigate the relationship between whole milk consumption and CAC progression, and the potential effect of SCFA in it. Methods We analyzed a population-based cohort with 5273 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who completed a dietary questionnaire at baseline. CAC was measured at baseline and subsequent follow-up examinations by multi-detector computed tomography (MDCT) scans with Agatston scores. CAC progression was defined as increased CAC scores in the follow-up from the baseline exam. Results Participants consuming whole milk exhibited lower baseline CAC and CAC progression than those who never/rarely consumed whole milk ( P  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-020-02301-5