Turn Conformation of β‑Amino Acid-Based Short Peptides Promoted by an Amidothiourea Moiety at C‑Terminus

A C-terminal amidothiourea motif is shown to promote a β-turn-like folded conformation in a series of β-amino acid-based short peptides in both the solid state and solution phase by an intramolecular 11-membered ring hydrogen bond.

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Bibliographic Details
Published in:Journal of organic chemistry 2020-08, Vol.85 (15), p.9844-9849
Main Authors: Zhang, Yanhan, Yan, Xiaosheng, Cao, Jinlian, Weng, Peimin, Miao, Daiyu, Li, Zhao, Jiang, Yun-Bao
Format: Article
Language:English
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Summary:A C-terminal amidothiourea motif is shown to promote a β-turn-like folded conformation in a series of β-amino acid-based short peptides in both the solid state and solution phase by an intramolecular 11-membered ring hydrogen bond.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c01139