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Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck
Background Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods We performed a...
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| Published in: | Head & neck 2020-10, Vol.42 (10), p.2830-2840 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 2840 |
| container_issue | 10 |
| container_start_page | 2830 |
| container_title | Head & neck |
| container_volume | 42 |
| creator | Ferrandino, Rocco M. Roof, Scott Garneau, Jonathan Haidar, Yarah Bates, Susan E. Park, Yeun‐Hee A. Bauml, Joshua M. Genden, Eric M. Miles, Brett Sigel, Keith |
| description | Background
Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.
Methods
We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates.
Results
The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P |
| doi_str_mv | 10.1002/hed.26329 |
| format | article |
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Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.
Methods
We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates.
Results
The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P < .001) and 44% increased hazard of cancer‐specific mortality (P < .001) at 5 years.
Conclusions
Elevated NLR in HNSCC confers a poor prognosis.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26329</identifier><identifier>PMID: 32592262</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer ; Cell survival ; Head & neck cancer ; head and neck squamous cell carcinoma ; Laryngeal cancer ; laryngeal carcinoma ; Lymphocytes ; Medical prognosis ; Mortality ; Neutrophils ; neutrophil‐to‐lymphocyte ratio ; oral cavity carcinoma ; oropharyngeal carcinoma ; Prognosis ; Solid tumors ; Squamous cell carcinoma ; Throat cancer</subject><ispartof>Head & neck, 2020-10, Vol.42 (10), p.2830-2840</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-87764f2d7ec8748370bab49791dca85ebe1dd813e96545b06c05dba2bf1f1c583</citedby><cites>FETCH-LOGICAL-c3539-87764f2d7ec8748370bab49791dca85ebe1dd813e96545b06c05dba2bf1f1c583</cites><orcidid>0000-0002-4880-6172 ; 0000-0001-8567-7982 ; 0000-0003-2092-0296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32592262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrandino, Rocco M.</creatorcontrib><creatorcontrib>Roof, Scott</creatorcontrib><creatorcontrib>Garneau, Jonathan</creatorcontrib><creatorcontrib>Haidar, Yarah</creatorcontrib><creatorcontrib>Bates, Susan E.</creatorcontrib><creatorcontrib>Park, Yeun‐Hee A.</creatorcontrib><creatorcontrib>Bauml, Joshua M.</creatorcontrib><creatorcontrib>Genden, Eric M.</creatorcontrib><creatorcontrib>Miles, Brett</creatorcontrib><creatorcontrib>Sigel, Keith</creatorcontrib><title>Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.
Methods
We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates.
Results
The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P < .001) and 44% increased hazard of cancer‐specific mortality (P < .001) at 5 years.
Conclusions
Elevated NLR in HNSCC confers a poor prognosis.</description><subject>Cancer</subject><subject>Cell survival</subject><subject>Head & neck cancer</subject><subject>head and neck squamous cell carcinoma</subject><subject>Laryngeal cancer</subject><subject>laryngeal carcinoma</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>neutrophil‐to‐lymphocyte ratio</subject><subject>oral cavity carcinoma</subject><subject>oropharyngeal carcinoma</subject><subject>Prognosis</subject><subject>Solid tumors</subject><subject>Squamous cell carcinoma</subject><subject>Throat cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kb1O3TAYhi1UVCh06A0gS13oEPBf4mREQEslBAvM0Rf7CzFN4mAnB52tl9Ct99crqQ8HlkodbH-yHj96rZeQT5ydcMbEaYf2RBRSVDtkn7NKZ0wq_W4zK5lJptUe-RDjI2NMFkq8J3tS5JUQhdgnv29wmYOfOtf_-flr9mnr18PUebOekQaYnacQKdAp-IfRx9kZ6kbrDMw-0DYtv8IAfU9htNTAaDAkR5zQuDaxcQkrt4I-PaLxaYHBL5EaTLyBYNzoB6C-pXOHtEOwL5YRzY9DsttCH_Hj63lA7r9e3p1fZde3376fn11nRuayykqtC9UKq9GUWpVSswYaVemKWwNljg1ya0susSpylTesMCy3DYim5S03eSkPyPHWm_73tGCc68HFTT4YMUWtheIlF0oWLKGf_0Ef_RLGlC5RihWs1DxP1JctZYKPMWBbT8ENENY1Z_WmrTq1Vb-0ldijV-PSDOn2jXyrJwGnW-DZ9bj-v6m-urzYKv8COT-jcQ</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Ferrandino, Rocco M.</creator><creator>Roof, Scott</creator><creator>Garneau, Jonathan</creator><creator>Haidar, Yarah</creator><creator>Bates, Susan E.</creator><creator>Park, Yeun‐Hee A.</creator><creator>Bauml, Joshua M.</creator><creator>Genden, Eric M.</creator><creator>Miles, Brett</creator><creator>Sigel, Keith</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4880-6172</orcidid><orcidid>https://orcid.org/0000-0001-8567-7982</orcidid><orcidid>https://orcid.org/0000-0003-2092-0296</orcidid></search><sort><creationdate>202010</creationdate><title>Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck</title><author>Ferrandino, Rocco M. ; Roof, Scott ; Garneau, Jonathan ; Haidar, Yarah ; Bates, Susan E. ; Park, Yeun‐Hee A. ; Bauml, Joshua M. ; Genden, Eric M. ; Miles, Brett ; Sigel, Keith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-87764f2d7ec8748370bab49791dca85ebe1dd813e96545b06c05dba2bf1f1c583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer</topic><topic>Cell survival</topic><topic>Head & neck cancer</topic><topic>head and neck squamous cell carcinoma</topic><topic>Laryngeal cancer</topic><topic>laryngeal carcinoma</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>neutrophil‐to‐lymphocyte ratio</topic><topic>oral cavity carcinoma</topic><topic>oropharyngeal carcinoma</topic><topic>Prognosis</topic><topic>Solid tumors</topic><topic>Squamous cell carcinoma</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrandino, Rocco M.</creatorcontrib><creatorcontrib>Roof, Scott</creatorcontrib><creatorcontrib>Garneau, Jonathan</creatorcontrib><creatorcontrib>Haidar, Yarah</creatorcontrib><creatorcontrib>Bates, Susan E.</creatorcontrib><creatorcontrib>Park, Yeun‐Hee A.</creatorcontrib><creatorcontrib>Bauml, Joshua M.</creatorcontrib><creatorcontrib>Genden, Eric M.</creatorcontrib><creatorcontrib>Miles, Brett</creatorcontrib><creatorcontrib>Sigel, Keith</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrandino, Rocco M.</au><au>Roof, Scott</au><au>Garneau, Jonathan</au><au>Haidar, Yarah</au><au>Bates, Susan E.</au><au>Park, Yeun‐Hee A.</au><au>Bauml, Joshua M.</au><au>Genden, Eric M.</au><au>Miles, Brett</au><au>Sigel, Keith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-10</date><risdate>2020</risdate><volume>42</volume><issue>10</issue><spage>2830</spage><epage>2840</epage><pages>2830-2840</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.
Methods
We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates.
Results
The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P < .001) and 44% increased hazard of cancer‐specific mortality (P < .001) at 5 years.
Conclusions
Elevated NLR in HNSCC confers a poor prognosis.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32592262</pmid><doi>10.1002/hed.26329</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4880-6172</orcidid><orcidid>https://orcid.org/0000-0001-8567-7982</orcidid><orcidid>https://orcid.org/0000-0003-2092-0296</orcidid></addata></record> |
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| ispartof | Head & neck, 2020-10, Vol.42 (10), p.2830-2840 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Cancer Cell survival Head & neck cancer head and neck squamous cell carcinoma Laryngeal cancer laryngeal carcinoma Lymphocytes Medical prognosis Mortality Neutrophils neutrophil‐to‐lymphocyte ratio oral cavity carcinoma oropharyngeal carcinoma Prognosis Solid tumors Squamous cell carcinoma Throat cancer |
| title | Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck |
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