Incidence of hypertension among Asian Indians: 10 year follow up of the Chennai Urban Rural Epidemiology Study (CURES-153)

• Published in: Journal of diabetes and its complications 2020-10, Vol.34 (10), p.107652-107652, Article 107652
• Main Authors: Mohan, Viswanathan, Anjana, Ranjit Mohan, Unnikrishnan, Ranjit, Venkatesan, Ulagamathesan, Uma Sankari, Ganesan, Rahulashankiruthiyayan, Thangarajan, Samhita, Sharat Kumar, Subramanian Shanthi Rani, Coimbatore
• Format: Article
• Language: English
• Subjects: Age; Alcohol use; Antihypertensives; Blood pressure; Body mass index; Cholesterol; Diabetes; Epidemiology; Family medical history; Fasting; Follow up study; Glucose; Hemoglobin; Hypertension; Incidence of hypertension; Laboratories; Plasma; Population; Potassium; Prediabetes; Questionnaires; Software; Triglycerides
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2020.107652

There are very few studies on incidence of hypertension from developing countries. We report on the incidence of hypertension and its risk factors in Chennai city in southern India. Participants were 1691 individuals from the Chennai Urban Rural Epidemiology Study (CURES) cohorts who did not have hypertension (normotensive n = 878, prehypertension n = 813) at baseline and who were followed for a median of 9.0 years. During the follow-up, 41 with missing blood pressure values were excluded, leaving 1650 individuals for the present analysis. Incidence rates of hypertension and predictors of progression to prehypertension and/or hypertension were estimated using Cox proportional hazards model. During the follow-up period, 426 out of 1650 individuals developed hypertension, giving an overall incidence of hypertension of 28.7(95%CI 26.1–31.5) per 1000 person-years. Individuals with dysglycemia at baseline had higher incident rates of hypertension. Collectively, four modifiable risk factors [pre-hypertension, dysglycemia, central obesity and physical inactivity] accounted for 87.2% of the population attributable risk of incident hypertension. Higher body weight, BMI, age and dysglycemia were associated with an increased risk of incident hypertension. Prehypertension, dysglycemia, central obesity and physical inactivity accounted for 87% of incident hypertension. •There are very few studies on incidence of hypertension from developing countries, especially from India.•Higher body weight, BMI, age and glucose intolerance were significantly associated with incident hypertension.•Individuals with prediabetes and/or diabetes at baseline, had higher incident rates of hypertension on follow up.•Prehypertension, dysglycemia, central obesity and physical inactivity accounted for 87% of incident hypertension.