Theta burst stimulation ameliorates symptoms of experimental autoimmune encephalomyelitis and attenuates reactive gliosis

•EAE induced increased astro- and microgliosis.•Treatment with theta burst stimulation attenuates reactive gliosis and downregualtes vimentin expression.•Both TBS protocols significantly reduced paralysis time.•Vimentin could be used as a potential biomarker of the disease. Multiple sclerosis (MS) i...

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Bibliographic Details
Published in:Brain research bulletin 2020-09, Vol.162, p.208-217
Main Authors: Dragic, Milorad, Zeljkovic, Milica, Stevanovic, Ivana, Ilic, Tihomir, Ilic, Nela, Nedeljkovic, Nadezda, Ninkovic, Milica
Format: Article
Language:English
Subjects:
Attenuation
EAE
Myelin
Reactive gliosis
rTMS
Vimentin
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Summary:•EAE induced increased astro- and microgliosis.•Treatment with theta burst stimulation attenuates reactive gliosis and downregualtes vimentin expression.•Both TBS protocols significantly reduced paralysis time.•Vimentin could be used as a potential biomarker of the disease. Multiple sclerosis (MS) is a chronic neurodegenerative disease caused by inflammatory processes in the central nervous system (CNS). Decades of research led to discovery of several disease-modifying therapeutics strategies with moderate success. Experimental autoimmune encephalomyelitis (EAE) is currently the most commonly used experimental model for MS and for studying various therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique with multiple beneficial effects on healthy as well as CNS with pathology. However, the molecular and cellular mechanisms of rTMS on acute EAE are scarce. Our study demonstrated beneficial effects of theta-burst stimulation (TBS), an experimental paradigm of rTMS, on disease course of acute EAE. TBS treatment attenuated reactive gliosis, restored myelin sheet and down-regulated expression of vimentin in EAE rats. These effects were reflected through reduced clinical parameters, shorter duration of illness and days spent in paralysis. Based on our research, rTMS deserves further considerations for its neuroprotective effect on EAE, and is an excellent candidate for further research and points that it could be used for more than for simple symptomatic therapy.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2020.06.013