Synthesis and Absolute Configuration of Habiterpenol

The synthesis of habiterpenol, a G2 checkpoint inhibitor, was achieved through the stereoselective Ti­(III)-mediated radical cyclization of a β-epoxide as the key reaction. Moreover, the absolute configuration of habiterpenol was determined.

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Bibliographic Details
Published in:Organic letters 2020-07, Vol.22 (13), p.5131-5134
Main Authors: Konya, Miyuki, Shimoyama, Kenta, Arima, Shiho, Fukuda, Takashi, Uchida, Ryuji, Tomoda, Hiroshi, Nagamitsu, Tohru
Format: Article
Language:English
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Summary:The synthesis of habiterpenol, a G2 checkpoint inhibitor, was achieved through the stereoselective Ti­(III)-mediated radical cyclization of a β-epoxide as the key reaction. Moreover, the absolute configuration of habiterpenol was determined.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01736