Rhodium(III)-Catalyzed Cyclopropane C–H/C–C Activation Sequence Provides Diastereoselective Access to α‑Alkoxylated γ‑Lactams

A Cp*Rh­(III)-catalyzed C–H/C–C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping of the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access to synthetically valuable α-alkoxylated γ-lactams with...

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Bibliographic Details
Published in:Organic letters 2020-07, Vol.22 (13), p.5030-5034
Main Authors: Audic, Benoit, Cramer, Nicolai
Format: Article
Language:English
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Summary:A Cp*Rh­(III)-catalyzed C–H/C–C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping of the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access to synthetically valuable α-alkoxylated γ-lactams with trans diastereoselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01606