Dermatofluoroscopy diagnostics in different pigmented skin lesions: Strengths and weaknesses

Summary Background The melanin fluorescence of skin lesions is measurable with two‐photon excitation, a process termed dermatofluoroscopy, which has shown a shift from the green spectra in benign melanocytic lesions to the red spectra in melanoma. This study addressed the question as to which kind o...

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Published in:Journal der Deutschen Dermatologischen Gesellschaft 2020-07, Vol.18 (7), p.682-690
Main Authors: Hofmann, Maja Ann, Keim, Ulrike, Jagoda, Agata, Forschner, Andrea, Fink, Christine, Spänkuch, Iris, Tampouri, Ioanna, Eigentler, Thomas, Weide, Benjamin, Haenssle, Holger A., Garbe, Claus
Format: Article
Language:English
Subjects:
Basal cell carcinoma
Carcinoma
Carcinoma, Basal Cell - diagnostic imaging
Children
Dermoscopy
Diagnosis
Diagnosis, Differential
Fluorescence
Fluoroscopy
Humans
Melanin
Melanocytes
Melanoma
Melanoma - diagnostic imaging
Melanoma, Cutaneous Malignant
Microscopy, Fluorescence, Multiphoton
Nevus, Pigmented - diagnostic imaging
Sensitivity and Specificity
Skin - pathology
Skin cancer
Skin diseases
Skin lesions
Skin Neoplasms - diagnostic imaging
Tanning
Tumors
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Summary:Summary Background The melanin fluorescence of skin lesions is measurable with two‐photon excitation, a process termed dermatofluoroscopy, which has shown a shift from the green spectra in benign melanocytic lesions to the red spectra in melanoma. This study addressed the question as to which kind of pigmented lesions can be correctly diagnosed as melanin‐bearing malignant tumors. Methods 476 pigmented lesions including 101 cutaneous melanomas were analyzed with dermatofluoroscopy, measuring the melanin fluorescence in a grid‐like fashion with a separation of measurement points of 0.2 mm. The results of the dermatofluoroscopy are presented as a diagnostic score with a cut‐off score of ≥ 28 for the diagnosis of melanin‐bearing malignant tumors, and were compared to the gold standard of histopathology. Results A highly significant difference (p 
ISSN:1610-0379
1610-0387
DOI:10.1111/ddg.14163