Evaluating the efficacy and safety of vascular IPL for treatment of acute cutaneous leishmaniasis: a randomized controlled trial

Treatment of cutaneous leishmaniasis (CL) continues to be a health concern, and alternative therapies with fewer side effects are substantially needed. This study aimed to determine the efficacy of intense pulsed light (IPL) with wavelength spectrum affecting vascular lesions on acute cutaneous leis...

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Bibliographic Details
Published in:Lasers in medical science 2021-04, Vol.36 (3), p.631-640
Main Authors: Tafazzoli, Zahra, Nahidi, Yalda, Mashayekhi Goyonlo, Vahid, Morovatdar, Negar, Layegh, Pouran
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Antiprotozoal Agents - therapeutic use
Blistering
Case-Control Studies
Cutaneous leishmaniasis
Dentistry
Female
Humans
Informed consent
Injections, Intralesional
Intense Pulsed Light Therapy - adverse effects
Intervention
Lasers
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - therapy
Lesions
Male
Medicine
Medicine & Public Health
Meglumine antimoniate
Meglumine Antimoniate - therapeutic use
Optical Devices
Optics
Original Article
Parasitic diseases
Patients
Photonics
Quantum Optics
Side effects
Treatment Outcome
Vector-borne diseases
Wavelength
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Summary:Treatment of cutaneous leishmaniasis (CL) continues to be a health concern, and alternative therapies with fewer side effects are substantially needed. This study aimed to determine the efficacy of intense pulsed light (IPL) with wavelength spectrum affecting vascular lesions on acute cutaneous leishmaniasis. In this randomized clinical trial study, 30 patients with acute CL were enrolled. Baseline clinical and demographic data were recorded in the checklist after obtaining written informed consent. Patients were randomly allocated to receive either IPL fortnightly (intervention group) or intralesional meglumine antimoniate (MA) weekly (control group) over 10 weeks. Patients were assessed every 2 weeks to determine the size of induration and improvement rate of lesions. Follow-up visits were arranged at 3rd and 6th months. Overall, 15 patients (21 lesions) in the intervention group and 15 patients (22 lesions) in the control group were studied. The size of lesions in the control group was significantly higher at the baseline ( P  = 0.014) and the second week ( P  = 0.034), and significantly lower in the eighth week ( P  = 0.009), compared with the intervention group. The size of lesions in the control group changed during the study ( P  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-020-03102-2