Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics

Summary Accumulating evidence suggests that a disruption of early brain development, in which insulin-like growth factor-2 (IGF-2) has a crucial role, may underlie the pathophysiology of schizophrenia. Our previous study has shown that decreased serum IGF-2 was correlated with the severity of psycho...

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Published in:Current medical science 2020-06, Vol.40 (3), p.563-569
Main Authors: Chao, Xue-lin, Jiang, Shu-zhen, Xiong, Jian-wen, Zhan, Jin-qiong, Wei, Bo, Chen, Chun-nuan, Yang, Yuan-jian
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - therapeutic use
Biomarkers - blood
Female
Humans
Insulin-Like Growth Factor II - metabolism
Male
Medicine
Medicine & Public Health
Prospective Studies
Schizophrenia - blood
Schizophrenia - drug therapy
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Summary:Summary Accumulating evidence suggests that a disruption of early brain development, in which insulin-like growth factor-2 (IGF-2) has a crucial role, may underlie the pathophysiology of schizophrenia. Our previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with schizophrenia. Here we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia patients. Thirty-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this study. Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and serum IGF-2 levels were determined using ELISA. We found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline ( P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-020-2214-0