Erectile dysfunction is associated with defective L-cysteine/hydrogen sulfide pathway in human corpus cavernosum and penile arteries

H2S signaling was proposed to participate in erectile physiology. L-cysteine (CYS)/H2S pathway stimulation causes cGMP-dependent relaxation of human corpus cavernosum (HCC) and penile arteries (HPRA). The aim was to evaluate the impact of ED on CYS/H2S pathway at functional and molecular level in hu...

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Published in:European journal of pharmacology 2020-10, Vol.884, p.173370-173370, Article 173370
Main Authors: La Fuente, José M., Sevilleja-Ortiz, Alejandro, García-Rojo, Esther, El Assar, Mariam, Fernández, Argentina, Pepe-Cardoso, Augusto J., Martínez-Salamanca, Juan I., Romero-Otero, Javier, Rodríguez-Mañas, Leocadio, Angulo, Javier
Format: Article
Language:English
Subjects:
Adult
Aged
Arteries - drug effects
Arteries - metabolism
Arteries - physiopathology
Cyclic GMP - metabolism
Cystathionine beta-Synthase - metabolism
Cystathionine gamma-Lyase - metabolism
Cystathionine β-synthase
Cystathionine γ-lyase
Cysteine - metabolism
Cysteine - pharmacology
Erectile dysfunction
Human corpus cavernosum
Humans
Hydrogen sulfide
Impotence, Vasculogenic - metabolism
Impotence, Vasculogenic - physiopathology
L-cysteine
Male
Middle Aged
Penile Erection - drug effects
Penis - blood supply
Regional Blood Flow
Signal Transduction
Sulfides - metabolism
Sulfides - pharmacology
Vasodilation - drug effects
Young Adult
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Summary:H2S signaling was proposed to participate in erectile physiology. L-cysteine (CYS)/H2S pathway stimulation causes cGMP-dependent relaxation of human corpus cavernosum (HCC) and penile arteries (HPRA). The aim was to evaluate the impact of ED on CYS/H2S pathway at functional and molecular level in human penile vascular tissues. NaHS- and CYS-induced responses were evaluated in HCC and HPRA from organ donors without ED (NoED, n = 29) and from ED patients undergoing penile prosthesis insertion (n = 45). cGMP accumulation and cystathionine β-synthase and cystathionine γ-lyase expression were also determined. NaHS-induced relaxations were slightly but significantly impaired in HCC but not in HPRA from ED patients. In contrast, CYS-induced relaxations were markedly impaired in HCC (Emax 67.6 ± 4.9% vs 46.2 ± 4.6%, P 
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2020.173370