Association Between Pretreatment Sleep Disturbance and Radiation Therapy-Induced Pain in 573 Women With Breast Cancer

Pain can be a debilitating side effect of radiation therapy (RT). Data from the general population have shown that sleep disturbance can influence pain incidence and severity; however, less is known about this relationship in patients with breast cancer receiving RT. This secondary analysis examined...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pain and symptom management 2021-02, Vol.61 (2), p.254-261
Main Authors: Peoples, Anita R., Pigeon, Wilfred R., Li, Dongmei, Garland, Sheila N., Perlis, Michael L., Inglis, Julia E., Vinciguerra, Vincent, Anderson, Thomas, Evans, Lisa S., Wade, James L., Ossip, Deborah J., Morrow, Gary R., Wolf, Julie Ryan
Format: Article
Language:English
Subjects:
affective pain
Anxiety disorders
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - radiotherapy
Cancer therapies
Chemotherapy
Clinical research
Clinical trials
Depression - epidemiology
Depression - etiology
Dermatitis
Fatigue
Fatigue - epidemiology
Fatigue - etiology
Female
Humans
Mastectomy
Pain
Pain - epidemiology
Pain - etiology
Radiation
Radiation therapy
sensory pain
Severity
Sleep
Sleep disorders
Sleep disturbance
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - etiology
Women
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pain can be a debilitating side effect of radiation therapy (RT). Data from the general population have shown that sleep disturbance can influence pain incidence and severity; however, less is known about this relationship in patients with breast cancer receiving RT. This secondary analysis examined the association of pretreatment moderate/severe levels of sleep disturbance with subsequent RT-induced pain after adjusting for pre-RT pain. We report on 573 female patients with breast cancer undergoing RT from a previously completed Phase II clinical trial for radiation dermatitis. Sleep disturbance, total pain, and pain subdomains—sensory pain, affective pain, and perceived pain intensity were assessed at pre-RT and post-RT. At pre-RT, patients were dichotomized into two groups: those with moderate/severe sleep disturbance (N = 85) vs. those with no/mild sleep disturbance (control; N = 488). At pre-RT, women with moderate/severe sleep disturbance were younger, less likely to be married, more likely to have had mastectomy and chemotherapy, and more likely to have depression/anxiety disorder and fatigue than the control group (all Ps 
ISSN:0885-3924
1873-6513
DOI:10.1016/j.jpainsymman.2020.07.041