Persistent inflammation, immunosuppression and catabolism syndrome (PICS) in critically ill children is associated with clinical outcomes: a prospective longitudinal study

Background Persistent inflammation, immunosuppression and catabolism syndrome (PICS) has been described in critically ill adults and may contribute to unfavourable outcomes. The present study aimed to describe and characterise PICS in critically ill children (PICS‐ped) and to verify its association...

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Bibliographic Details
Published in:Journal of human nutrition and dietetics 2021-04, Vol.34 (2), p.365-373
Main Authors: Hauschild, D. B., Oliveira, L. D. A., Ventura, J. C., Farias, M. S., Barbosa, E., Bresolin, N. L., Moreno, Y. M. F.
Format: Article
Language:English
Subjects:
Antibiotics
Arm circumference
Catabolism
Children
Clinical outcomes
Correlation analysis
Immunosuppression
Immunosuppressive agents
Inflammation
Length of stay
Longitudinal studies
Lymphocytes
Mechanical ventilation
Mortality
muscle protein
Nutrition
Nutrition therapy
Nutritional status
paediatric intensive care units
Regression analysis
Statistical analysis
Vasoactive agents
Ventilation
Ventilators
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Summary:Background Persistent inflammation, immunosuppression and catabolism syndrome (PICS) has been described in critically ill adults and may contribute to unfavourable outcomes. The present study aimed to describe and characterise PICS in critically ill children (PICS‐ped) and to verify its association with clinical outcomes. Methods A prospective longitudinal study was conducted in a paediatric intensive care unit (PICU) with children aged between 3 months and 15 years. PICS‐ped, based on adult definition, was described. PICS‐ped was defined as PICU length of stay >14 days; C‐reactive protein > 10.0 mg L−1; lymphocytes
ISSN:0952-3871
1365-277X
DOI:10.1111/jhn.12798