USP13 controls the stability of Aurora B impacting progression through the cell cycle

Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a balance between the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome (activated by the Cdh1 ad...

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Bibliographic Details
Published in:	Oncogene 2020-09, Vol.39 (37), p.6009-6023
Main Authors:	Esposito, Mara, Akman, H. Begum, Giron, Philippe, Ceregido, M. Angeles, Schepers, Rogier, Ramos Paez, Luis C., La Monaca, Esther, De Greve, Jacques, Coux, Olivier, De Trez, Carl, Lindon, Catherine, Gutierrez, Gustavo J.
Format:	Article
Language:	English
Subjects:	631/337/641 631/45/474/582 Anaphase Anaphase-promoting complex Apoptosis Aurora B protein Aurora Kinase B - metabolism Cell Biology Cell cycle Cell Cycle - genetics Cell Cycle Checkpoints - genetics Cell Line, Tumor Disease Progression E-cadherin Endopeptidases - genetics Endopeptidases - metabolism Enzyme Stability Gene Expression Gene Knockdown Techniques Human Genetics Humans Internal Medicine Interphase Kinases Life Sciences Ligases Medicine Medicine & Public Health Mitosis Oncology Phosphorylation Protein Binding Serine Serine - metabolism Ubiquitin Ubiquitin-protein ligase Ubiquitin-Specific Proteases
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