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Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation
Methicillin-resistant Staphylococcus aureus (MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in respon...
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| Published in: | Applied microbiology and biotechnology 2020-09, Vol.104 (18), p.7957-7970 |
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| cites | cdi_FETCH-LOGICAL-c479t-c873f15901931985ad826a2ca2ccd9667ba70083b1e8a010510e06fbec75e8993 |
| container_end_page | 7970 |
| container_issue | 18 |
| container_start_page | 7957 |
| container_title | Applied microbiology and biotechnology |
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| creator | Du, Hechao Zhou, Libang Lu, Zhaoxin Bie, Xiaomei Zhao, Haizhen Niu, Yan D. Lu, Fengxia |
| description | Methicillin-resistant
Staphylococcus aureus
(MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in response to sub-MIC (16 μg/mL) plantaricin GZ1-27 stress. In total, 1090 differentially expressed genes (
padj
1.2,
p
|
| doi_str_mv | 10.1007/s00253-020-10589-w |
| format | article |
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Staphylococcus aureus
(MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in response to sub-MIC (16 μg/mL) plantaricin GZ1-27 stress. In total, 1090 differentially expressed genes (
padj
< 0.05) and 418 differentially expressed proteins (fold change > 1.2,
p
< 0.05) were identified. Centralized protein expression clusters were predicted in biological functions (biofilm formation, DNA replication and repair, and heat-shock) and metabolic pathways (purine metabolism, amino acid metabolism, and biosynthesis of secondary metabolites). Moreover, a capacity of inhibition MRSA biofilm formation and killing biofilm cells were verified using crystal violet staining, scanning electron microscopy, and confocal laser-scanning microscopy. These findings yielded comprehensive new data regarding responses induced by plantaricin and could inform evidence-based methods to mitigate MRSA biofilm formation.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-020-10589-w</identifier><identifier>PMID: 32803295</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amino acids ; Anti-Bacterial Agents - pharmacology ; Bacteriocins ; Bacteriocins - genetics ; Biofilms ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; DNA repair ; DNA replication ; Drug resistance in microorganisms ; Genes ; Genomics ; Life Sciences ; Metabolic pathways ; Metabolism ; Metabolites ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - genetics ; Microbial Genetics and Genomics ; Microbial Sensitivity Tests ; Microbiology ; Microscopy ; Minimum inhibitory concentration ; Multidrug resistance ; Plant metabolites ; Protein folding ; Proteins ; Proteomics ; Scanning electron microscopy ; Scanning microscopy ; Secondary metabolites ; Staphylococcus aureus ; Staphylococcus infections ; Transcriptome ; Transcriptomics</subject><ispartof>Applied microbiology and biotechnology, 2020-09, Vol.104 (18), p.7957-7970</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-c873f15901931985ad826a2ca2ccd9667ba70083b1e8a010510e06fbec75e8993</citedby><cites>FETCH-LOGICAL-c479t-c873f15901931985ad826a2ca2ccd9667ba70083b1e8a010510e06fbec75e8993</cites><orcidid>0000-0001-9288-7419 ; 0000-0001-6148-7746 ; 0000-0003-0934-7847 ; 0000-0003-0937-9582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2436973364/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2436973364?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,11688,27924,27925,36060,36061,44363,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32803295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Hechao</creatorcontrib><creatorcontrib>Zhou, Libang</creatorcontrib><creatorcontrib>Lu, Zhaoxin</creatorcontrib><creatorcontrib>Bie, Xiaomei</creatorcontrib><creatorcontrib>Zhao, Haizhen</creatorcontrib><creatorcontrib>Niu, Yan D.</creatorcontrib><creatorcontrib>Lu, Fengxia</creatorcontrib><title>Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Methicillin-resistant
Staphylococcus aureus
(MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in response to sub-MIC (16 μg/mL) plantaricin GZ1-27 stress. In total, 1090 differentially expressed genes (
padj
< 0.05) and 418 differentially expressed proteins (fold change > 1.2,
p
< 0.05) were identified. Centralized protein expression clusters were predicted in biological functions (biofilm formation, DNA replication and repair, and heat-shock) and metabolic pathways (purine metabolism, amino acid metabolism, and biosynthesis of secondary metabolites). Moreover, a capacity of inhibition MRSA biofilm formation and killing biofilm cells were verified using crystal violet staining, scanning electron microscopy, and confocal laser-scanning microscopy. These findings yielded comprehensive new data regarding responses induced by plantaricin and could inform evidence-based methods to mitigate MRSA biofilm formation.</description><subject>Amino acids</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriocins</subject><subject>Bacteriocins - genetics</subject><subject>Biofilms</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA biosynthesis</subject><subject>DNA repair</subject><subject>DNA replication</subject><subject>Drug resistance in microorganisms</subject><subject>Genes</subject><subject>Genomics</subject><subject>Life Sciences</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Microscopy</subject><subject>Minimum inhibitory concentration</subject><subject>Multidrug resistance</subject><subject>Plant metabolites</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Scanning electron microscopy</subject><subject>Scanning microscopy</subject><subject>Secondary metabolites</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Transcriptome</subject><subject>Transcriptomics</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp9Ul1rFDEUHUSxa_UP-CABXyo4NR8z-XhcilahItj64kvIZO_spswkY5Kx9J_588zsVosikkCSe8-5Obk5VfWc4FOCsXiTMKYtqzHFNcGtVPXNg2pFGkZrzEnzsFphItpatEoeVU9SusaYUMn54-qIUYkZVe2q-nEVjU82uimH0Vlk_AZNMWTYn8qud4PzWxQhTcEnQKFHI-Sds24oibrEXcrGZ3SZzbS7HYIN1s4JmTlCWU4-fr5cv0I5IIN8-A4D6ozNEF2wzr9G01CoJpZqHp1_JTUVewUuJ-T8znUuu-CXOzu3KBlRH-JoluDT6lFvhgTP7tbj6su7t1dn7-uLT-cfztYXtW2EyrWVgvWkVZgoRpRszUZSbqgt024U56IzAmPJOgLS4NJGggHzvgMrWpBKsePq5FC39OLbDCnr0SULQxEOYU6aNqwRjaRsgb78C3od5uiLugXFlWCMN_eorRlAO9-HHI1diuo1Z6zlqiUL6vQfqDI2UD4meCjdgD8J9ECwMaQUoddTdKOJt5pgvdhFH-yii1303i76ppBe3CmeuxE2vym__FEA7ABIJeW3EO-f9J-yPwE9psxn</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Du, Hechao</creator><creator>Zhou, Libang</creator><creator>Lu, Zhaoxin</creator><creator>Bie, Xiaomei</creator><creator>Zhao, Haizhen</creator><creator>Niu, Yan D.</creator><creator>Lu, Fengxia</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9288-7419</orcidid><orcidid>https://orcid.org/0000-0001-6148-7746</orcidid><orcidid>https://orcid.org/0000-0003-0934-7847</orcidid><orcidid>https://orcid.org/0000-0003-0937-9582</orcidid></search><sort><creationdate>20200901</creationdate><title>Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation</title><author>Du, Hechao ; Zhou, Libang ; Lu, Zhaoxin ; Bie, Xiaomei ; Zhao, Haizhen ; Niu, Yan D. ; Lu, Fengxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-c873f15901931985ad826a2ca2ccd9667ba70083b1e8a010510e06fbec75e8993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Hechao</au><au>Zhou, Libang</au><au>Lu, Zhaoxin</au><au>Bie, Xiaomei</au><au>Zhao, Haizhen</au><au>Niu, Yan D.</au><au>Lu, Fengxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>104</volume><issue>18</issue><spage>7957</spage><epage>7970</epage><pages>7957-7970</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Methicillin-resistant
Staphylococcus aureus
(MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in response to sub-MIC (16 μg/mL) plantaricin GZ1-27 stress. In total, 1090 differentially expressed genes (
padj
< 0.05) and 418 differentially expressed proteins (fold change > 1.2,
p
< 0.05) were identified. Centralized protein expression clusters were predicted in biological functions (biofilm formation, DNA replication and repair, and heat-shock) and metabolic pathways (purine metabolism, amino acid metabolism, and biosynthesis of secondary metabolites). Moreover, a capacity of inhibition MRSA biofilm formation and killing biofilm cells were verified using crystal violet staining, scanning electron microscopy, and confocal laser-scanning microscopy. These findings yielded comprehensive new data regarding responses induced by plantaricin and could inform evidence-based methods to mitigate MRSA biofilm formation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32803295</pmid><doi>10.1007/s00253-020-10589-w</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9288-7419</orcidid><orcidid>https://orcid.org/0000-0001-6148-7746</orcidid><orcidid>https://orcid.org/0000-0003-0934-7847</orcidid><orcidid>https://orcid.org/0000-0003-0937-9582</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2020-09, Vol.104 (18), p.7957-7970 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2434748239 |
| source | ABI/INFORM Global; Springer Nature |
| subjects | Amino acids Anti-Bacterial Agents - pharmacology Bacteriocins Bacteriocins - genetics Biofilms Biomedical and Life Sciences Biosynthesis Biotechnology Deoxyribonucleic acid DNA DNA biosynthesis DNA repair DNA replication Drug resistance in microorganisms Genes Genomics Life Sciences Metabolic pathways Metabolism Metabolites Methicillin Methicillin-Resistant Staphylococcus aureus - genetics Microbial Genetics and Genomics Microbial Sensitivity Tests Microbiology Microscopy Minimum inhibitory concentration Multidrug resistance Plant metabolites Protein folding Proteins Proteomics Scanning electron microscopy Scanning microscopy Secondary metabolites Staphylococcus aureus Staphylococcus infections Transcriptome Transcriptomics |
| title | Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation |
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