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A Systematic Literature Review of Peripheral Nerve Stimulation Therapies for the Treatment of Pain

Abstract Objective To conduct a systematic literature review of peripheral nerve stimulation (PNS) for pain. Design Grade the evidence for PNS. Methods An international interdisciplinary work group conducted a literature search for PNS. Abstracts were reviewed to select studies for grading. Inclusio...

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Published in:Pain medicine (Malden, Mass.) Mass.), 2020-08, Vol.21 (8), p.1590-1603
Main Authors: Deer, Timothy R, Esposito, Michael F, McRoberts, W Porter, Grider, Jay S, Sayed, Dawood, Verrills, Paul, Lamer, Tim J, Hunter, Corey W, Slavin, Konstantin V, Shah, Jay M, Hagedorn, Jonathan M, Simopoulos, Tom, Gonzalez, David Abejon, Amirdelfan, Kasra, Jain, Sameer, Yang, Ajax, Aiyer, Rohit, Antony, Ajay, Azeem, Nomen, Levy, Robert M, Mekhail, Nagy
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Language:English
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Summary:Abstract Objective To conduct a systematic literature review of peripheral nerve stimulation (PNS) for pain. Design Grade the evidence for PNS. Methods An international interdisciplinary work group conducted a literature search for PNS. Abstracts were reviewed to select studies for grading. Inclusion/exclusion criteria included prospective randomized controlled trials (RCTs) with meaningful clinical outcomes that were not part of a larger or previously reported group. Excluded studies were retrospective, had less than two months of follow-up, or existed only as abstracts. Full studies were graded by two independent reviewers using the modified Interventional Pain Management Techniques–Quality Appraisal of Reliability and Risk of Bias Assessment, the Cochrane Collaborations Risk of Bias assessment, and the US Preventative Services Task Force level-of-evidence criteria. Results Peripheral nerve stimulation was studied in 14 RCTs for a variety of painful conditions (headache, shoulder, pelvic, back, extremity, and trunk pain). Moderate to strong evidence supported the use of PNS to treat pain. Conclusion Peripheral nerve stimulation has moderate/strong evidence. Additional prospective trials could further refine appropriate populations and pain diagnoses.
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnaa030