Association between intracranial aneurysm and meningiomas: An integrative survival Analysis with identification of prognostic factors

• Published in: Clinical neurology and neurosurgery 2020-11, Vol.198, p.106128-106128, Article 106128
• Main Authors: de Souza, Matheus Rodrigues, Fagundes, Caroline Ferreira, Rabelo, Nicollas Nunes, Teixeira, Manoel Jacobsen, Figueiredo, Eberval Gadelha
• Format: Article
• Language: English
• Subjects: Age; Aneurysm; Aneurysms; Brain cancer; Brain tumor; Carotid artery; Cysts; Gender; Intracranial aneurysm; Medical prognosis; Meningioma; Multivariate analysis; Neurology; Prognostic factor; Regression analysis; Statistical analysis; Subarachnoid hemorrhage; Survival; Survival analysis; Tumors
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2020.106128

•Association between Meningioma and intracranial aneurysms (IA) is uncommon 0.7 %–7,7%.•We sought the literature in order to study prognostic factors associated with this occurrence.•77.9 % of Aneurysms were ipsilateral of the tumor; 25.97 % exclusively (SAH).•Aneurysm rupture was associated with a worse patient prognosis.•Unruptured aneurysms and treatment were protective independent factors for OS. To analyze prognostic factors in clinical association between intracranial aneurysm (IA) and meningioma. Prognostic factors on overall survival (OS) were evaluated. We selected articles, published from January 1944 to December 2018 on the Medical databases (Web of Sciences, Medline and EMBASE) and included case series and reports. Clinical information was obtained and variables associated with the primary outcome of 27-mo survival were identified through Cox regression models. The study evaluated 77 patients. Female represented 76.6 % (n = 59), a ratio of 3.27 female: 1 male. The age range was 7–84 years old, with an average of 54.74 (SD: 14.30). Age and sex were not significant statistically different between the two groups for overall survival (OS) (log-rank P = 0.806), (log-rank P = 0.983) respectively. 77.9 % (n = 60) were ipsilateral, the same side was 4 times more common in univariate analysis (P = 0.052; 95 % CI, 0.924–17.319). Most aneurysms were detected in the internal carotid artery, 29.87 %. In Clinical data, 62.33 % (n = 48) had exclusive tumor symptoms, while 25.97 % (n = 20) presented exclusively subarachnoid hemorrhage (SAH). In multivariate analysis, although there is an independent protective factor for those who did not have SAH (HR; 0.099; CI; 0.010−0.986; P = 0.049) and the treatment is an independent predictor for OS (HR, 42.096; CI, 4.270–415.056; P = 0.01). This is the first study to approach this association. This is not just an occasional finding, but it seems to have a shared pathophysiology. Unruptured aneurysms and treatment modality were protective independent factors for OS. Prospective studies are warranted to provide definitive answers.