Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry

• Published in: Rheumatology (Oxford, England) England), 2021-03, Vol.60 (3), p.1125-1136
• Main Authors: López-Medina, Clementina, Ortega-Castro, Rafaela, Castro-Villegas, M Carmen, Font-Ugalde, Pilar, Puche-Larrubia, M Ángeles, Gómez-García, Ignacio, Arias-de la Rosa, Iván, Barbarroja, Nuria, Schiotis, Ruxandra, Collantes-Estévez, Eduardo
• Format: Article
• Language: English
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/keaa398

Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake. Results A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P